{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9S7Q7","uniProtkbId":"FLC_ARATH","entryAudit":{"firstPublicDate":"2001-12-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":177,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10330478"}],"value":"MADS-box protein FLOWERING LOCUS C"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10072403"}],"value":"MADS-box protein FLOWERING LOCUS F"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10330478"}],"value":"FLC"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10072403"}],"value":"FLF"}],"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Araport","id":"AT5G10140"}],"value":"At5g10140"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"CAB92055.1"}],"value":"T31P16.130"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10716723"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11283346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19121105"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25267112"}],"value":"Putative transcription factor that seems to play a central role in the regulation of flowering time in the late-flowering phenotype by interacting with 'FRIGIDA', the autonomous and the vernalization flowering pathways. Inhibits flowering by repressing 'SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1'. At elevated temperatures (e.g. 29 degrees Celsius), maintained at high levels in a JMJ30/JMJ32-dependent manner to prevent extreme precocious flowering (PubMed:25267112)"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9S7Q7","intActId":"EBI-2127872"},"interactantTwo":{"uniProtKBAccession":"Q9FVC1","geneName":"SVP","intActId":"EBI-592058"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00251"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00768"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9S7Q7-1"],"isoformSequenceStatus":"Displayed"}],"note":{"texts":[{"value":"A number of isoforms are produced. According to EST sequences."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19121105"}],"value":"High expression in the vegetative apex and in root tissue and lower expression in leaves and stems. Not detected in young tissues of the inflorescence. Before fertilization, expressed in ovules, but not in pollen or stamens, of non-vernalized plants. After vernalization, not detected in ovules"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18375656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19121105"}],"value":"Found in shoots of non-flowering plants grown under long-day conditions at days 4 to 15, and in shoots of plants grown under short-day conditions at days 4 to 11 after germination (PubMed:19121105). Expressed in embryos from the early globular stage (PubMed:19121105). FLC is not imprinted and both parental alleles contribute equally to expression in embryos (PubMed:19121105). Expression is repressed during gametogenesis, and is then reactivated after fertilization in embryos (PubMed:19121105). In seedlings, observed in the vasculature of the cotyledons, hypocotyls, and the first pair of leaves (PubMed:18375656). Just prior to flowering, a strong reduction in expression levels occurs in the vasculature (PubMed:18375656)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14712276"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15659097"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18573194"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19783648"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22904146"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25267112"}],"value":"Epigenetically down-regulated by vernalization. Vernalization repression is initiated by VIN3. Repressed by silencing mediated by polycomb group (PcG) protein complex containing EMF1 and EMF2. Up-regulated by HUA2. Down-regulated by VOZ1 and/or VOZ2. Down-regulated by RBG7. Accumulates at elevated temperatures via a JMJ30/JMJ32-mediated epigenetic regulation (e.g. removal of the repressive histone modification H3 lysine 27 trimethylation (H3K27me3)) (PubMed:25267112)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25267112"}],"value":"Early-flowering phenotype at elevated temperatures (e.g. 29 degrees Celsius) but not at room temperature (e.g. 22 degrees Celsius)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"value":"Prevention of early flowering by expression of FLC requires methylation of 'Lys-36' of histone H3. Repression of FLC is dependent on histone H3 'Lys-4' methylation which is partly controlled by the lysine-specific demthylase 1 (LSD1) homologs, LDL1, LDL2 and FLD. May also be regulated by the level of histone acetylation"}],"commentType":"MISCELLANEOUS"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"MADS-box protein FLOWERING LOCUS C","featureId":"PRO_0000199481"},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"MADS-box","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00251"}]},{"type":"Domain","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"K-box","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00629"}]},{"type":"Motif","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00768"}]}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0287","category":"Biological process","name":"Flowering"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"10072403","citationType":"journal article","authors":["Sheldon C.C.","Burn J.E.","Perez P.P.","Metzger J.","Edwards J.A.","Peacock W.J.","Dennis E.S."],"citationCrossReferences":[{"database":"PubMed","id":"10072403"},{"database":"DOI","id":"10.1105/tpc.11.3.445"}],"title":"The FLF MADS box gene: a repressor of flowering in Arabidopsis regulated by vernalization and methylation.","publicationDate":"1999","journal":"Plant Cell","firstPage":"445","lastPage":"458","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]"],"referenceComments":[{"value":"cv. C24","type":"STRAIN"},{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"10330478","citationType":"journal article","authors":["Michaels S.D.","Amasino R.M."],"citationCrossReferences":[{"database":"PubMed","id":"10330478"},{"database":"DOI","id":"10.1105/tpc.11.5.949"}],"title":"FLOWERING LOCUS C encodes a novel MADS domain protein that acts as a repressor of flowering.","publicationDate":"1999","journal":"Plant Cell","firstPage":"949","lastPage":"956","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"11130714","citationType":"journal article","authors":["Tabata S.","Kaneko T.","Nakamura Y.","Kotani H.","Kato T.","Asamizu E.","Miyajima N.","Sasamoto S.","Kimura T.","Hosouchi T.","Kawashima K.","Kohara M.","Matsumoto M.","Matsuno A.","Muraki A.","Nakayama S.","Nakazaki N.","Naruo K.","Okumura S.","Shinpo S.","Takeuchi C.","Wada T.","Watanabe A.","Yamada M.","Yasuda M.","Sato S.","de la Bastide M.","Huang E.","Spiegel L.","Gnoj L.","O'Shaughnessy A.","Preston R.","Habermann K.","Murray J.","Johnson D.","Rohlfing T.","Nelson J.","Stoneking T.","Pepin K.","Spieth J.","Sekhon M.","Armstrong J.","Becker M.","Belter E.","Cordum H.","Cordes M.","Courtney L.","Courtney W.","Dante M.","Du H.","Edwards J.","Fryman J.","Haakensen B.","Lamar E.","Latreille P.","Leonard S.","Meyer R.","Mulvaney E.","Ozersky P.","Riley A.","Strowmatt C.","Wagner-McPherson C.","Wollam A.","Yoakum M.","Bell M.","Dedhia N.","Parnell L.","Shah R.","Rodriguez M.","Hoon See L.","Vil D.","Baker J.","Kirchoff K.","Toth K.","King L.","Bahret A.","Miller B.","Marra M.A.","Martienssen R.","McCombie W.R.","Wilson R.K.","Murphy G.","Bancroft I.","Volckaert G.","Wambutt R.","Duesterhoeft A.","Stiekema W.","Pohl T.","Entian K.-D.","Terryn N.","Hartley N.","Bent E.","Johnson S.","Langham S.-A.","McCullagh B.","Robben J.","Grymonprez B.","Zimmermann W.","Ramsperger U.","Wedler H.","Balke K.","Wedler E.","Peters S.","van Staveren M.","Dirkse W.","Mooijman P.","Klein Lankhorst R.","Weitzenegger T.","Bothe G.","Rose M.","Hauf J.","Berneiser S.","Hempel S.","Feldpausch M.","Lamberth S.","Villarroel R.","Gielen J.","Ardiles W.","Bents O.","Lemcke K.","Kolesov G.","Mayer K.F.X.","Rudd S.","Schoof H.","Schueller C.","Zaccaria P.","Mewes H.-W.","Bevan M.","Fransz P.F."],"citationCrossReferences":[{"database":"PubMed","id":"11130714"},{"database":"DOI","id":"10.1038/35048507"}],"title":"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.","publicationDate":"2000","journal":"Nature","firstPage":"823","lastPage":"826","volume":"408"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"10716723","citationType":"journal article","authors":["Sheldon C.C.","Rouse D.T.","Finnegan E.J.","Peacock W.J.","Dennis E.S."],"citationCrossReferences":[{"database":"PubMed","id":"10716723"},{"database":"DOI","id":"10.1073/pnas.97.7.3753"}],"title":"The molecular basis of vernalization: the central role of FLOWERING LOCUS C (FLC).","publicationDate":"2000","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"3753","lastPage":"3758","volume":"97"},"referencePositions":["FUNCTION"],"referenceComments":[{"value":"cv. Pi-0","type":"STRAIN"}]},{"referenceNumber":7,"citation":{"id":"11283346","citationType":"journal article","authors":["Michaels S.D.","Amasino R.M."],"citationCrossReferences":[{"database":"PubMed","id":"11283346"},{"database":"DOI","id":"10.1105/tpc.13.4.935"}],"title":"Loss of flowering locus c activity eliminates the late-flowering phenotype of frigida and autonomous pathway mutations but not responsiveness to vernalization.","publicationDate":"2001","journal":"Plant Cell","firstPage":"935","lastPage":"942","volume":"13"},"referencePositions":["FUNCTION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":8,"citation":{"id":"14593187","citationType":"journal article","authors":["He Y.","Michaels S.D.","Amasino R.M."],"citationCrossReferences":[{"database":"PubMed","id":"14593187"},{"database":"DOI","id":"10.1126/science.1091109"}],"title":"Regulation of flowering time by histone acetylation in Arabidopsis.","publicationDate":"2003","journal":"Science","firstPage":"1751","lastPage":"1754","volume":"302"},"referencePositions":["REGULATION"]},{"referenceNumber":9,"citation":{"id":"14712276","citationType":"journal article","authors":["Sung S.","Amasino R.M."],"citationCrossReferences":[{"database":"PubMed","id":"14712276"},{"database":"DOI","id":"10.1038/nature02195"}],"title":"Vernalization in Arabidopsis thaliana is mediated by the PHD finger protein VIN3.","publicationDate":"2004","journal":"Nature","firstPage":"159","lastPage":"164","volume":"427"},"referencePositions":["INDUCTION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":10,"citation":{"id":"16299497","citationType":"journal article","authors":["Zhao Z.","Yu Y.","Meyer D.","Wu C.","Shen W.-H."],"citationCrossReferences":[{"database":"PubMed","id":"16299497"},{"database":"DOI","id":"10.1038/ncb1329"}],"title":"Prevention of early flowering by expression of FLOWERING LOCUS C requires methylation of histone H3 K36.","publicationDate":"2005","journal":"Nat. Cell Biol.","firstPage":"1256","lastPage":"1260","volume":"7"},"referencePositions":["REGULATION"]},{"referenceNumber":11,"citation":{"id":"15659097","citationType":"journal article","authors":["Doyle M.R.","Bizzell C.M.","Keller M.R.","Michaels S.D.","Song J.","Noh Y.-S.","Amasino R.M."],"citationCrossReferences":[{"database":"PubMed","id":"15659097"},{"database":"DOI","id":"10.1111/j.1365-313x.2004.02300.x"}],"title":"HUA2 is required for the expression of floral repressors in Arabidopsis thaliana.","publicationDate":"2005","journal":"Plant J.","firstPage":"376","lastPage":"385","volume":"41"},"referencePositions":["INDUCTION BY HUA2"]},{"referenceNumber":12,"citation":{"id":"17996704","citationType":"journal article","authors":["Liu F.","Quesada V.","Crevillen P.","Baeurle I.","Swiezewski S.","Dean C."],"citationCrossReferences":[{"database":"PubMed","id":"17996704"},{"database":"DOI","id":"10.1016/j.molcel.2007.10.018"}],"title":"The Arabidopsis RNA-binding protein FCA requires a lysine-specific demethylase 1 homolog to downregulate FLC.","publicationDate":"2007","journal":"Mol. Cell","firstPage":"398","lastPage":"407","volume":"28"},"referencePositions":["REGULATION"]},{"referenceNumber":13,"citation":{"id":"17921315","citationType":"journal article","authors":["Jiang D.","Yang W.","He Y.","Amasino R.M."],"citationCrossReferences":[{"database":"PubMed","id":"17921315"},{"database":"DOI","id":"10.1105/tpc.107.052373"}],"title":"Arabidopsis relatives of the human lysine-specific demethylase1 repress the expression of FWA and FLOWERING LOCUS C and thus promote the floral transition.","publicationDate":"2007","journal":"Plant Cell","firstPage":"2975","lastPage":"2987","volume":"19"},"referencePositions":["REGULATION"]},{"referenceNumber":14,"citation":{"id":"18375656","citationType":"journal article","authors":["Pien S.","Fleury D.","Mylne J.S.","Crevillen P.","Inze D.","Avramova Z.","Dean C.","Grossniklaus U."],"citationCrossReferences":[{"database":"PubMed","id":"18375656"},{"database":"DOI","id":"10.1105/tpc.108.058172"}],"title":"ARABIDOPSIS TRITHORAX1 dynamically regulates FLOWERING LOCUS C activation via histone 3 lysine 4 trimethylation.","publicationDate":"2008","journal":"Plant Cell","firstPage":"580","lastPage":"588","volume":"20"},"referencePositions":["REGULATION BY ATX1","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"},{"value":"cv. Wassilewskija","type":"STRAIN"}]},{"referenceNumber":15,"citation":{"id":"18573194","citationType":"journal article","authors":["Streitner C.","Danisman S.","Wehrle F.","Schoening J.C.","Alfano J.R.","Staiger D."],"citationCrossReferences":[{"database":"PubMed","id":"18573194"},{"database":"DOI","id":"10.1111/j.1365-313x.2008.03591.x"}],"title":"The small glycine-rich RNA binding protein AtGRP7 promotes floral transition in Arabidopsis thaliana.","publicationDate":"2008","journal":"Plant J.","firstPage":"239","lastPage":"250","volume":"56"},"referencePositions":["INDUCTION BY RBG7"]},{"referenceNumber":16,"citation":{"id":"19121105","citationType":"journal article","authors":["Choi J.","Hyun Y.","Kang M.J.","In Yun H.","Yun J.Y.","Lister C.","Dean C.","Amasino R.M.","Noh B.","Noh Y.S.","Choi Y."],"citationCrossReferences":[{"database":"PubMed","id":"19121105"},{"database":"DOI","id":"10.1111/j.1365-313x.2008.03776.x"}],"title":"Resetting and regulation of Flowering Locus C expression during Arabidopsis reproductive development.","publicationDate":"2009","journal":"Plant J.","firstPage":"918","lastPage":"931","volume":"57"},"referencePositions":["FUNCTION","DEVELOPMENTAL STAGE","TISSUE SPECIFICITY"]},{"referenceNumber":17,"citation":{"id":"19783648","citationType":"journal article","authors":["Kim S.Y.","Zhu T.","Sung Z.R."],"citationCrossReferences":[{"database":"PubMed","id":"19783648"},{"database":"DOI","id":"10.1104/pp.109.143495"}],"title":"Epigenetic regulation of gene programs by EMF1 and EMF2 in Arabidopsis.","publicationDate":"2010","journal":"Plant Physiol.","firstPage":"516","lastPage":"528","volume":"152"},"referencePositions":["INDUCTION BY EMF1 AND EMF2"]},{"referenceNumber":18,"citation":{"id":"22904146","citationType":"journal article","authors":["Yasui Y.","Mukougawa K.","Uemoto M.","Yokofuji A.","Suzuri R.","Nishitani A.","Kohchi T."],"citationCrossReferences":[{"database":"PubMed","id":"22904146"},{"database":"DOI","id":"10.1105/tpc.112.101915"}],"title":"The phytochrome-interacting VASCULAR PLANT ONE-ZINC FINGER1 and VOZ2 redundantly regulate flowering in Arabidopsis.","publicationDate":"2012","journal":"Plant Cell","firstPage":"3248","lastPage":"3263","volume":"24"},"referencePositions":["INDUCTION"]},{"referenceNumber":19,"citation":{"id":"25267112","citationType":"journal article","authors":["Gan E.-S.","Xu Y.","Wong J.-Y.","Goh J.G.","Sun B.","Wee W.-Y.","Huang J.","Ito T."],"citationCrossReferences":[{"database":"PubMed","id":"25267112"},{"database":"DOI","id":"10.1038/ncomms6098"}],"title":"Jumonji demethylases moderate precocious flowering at elevated temperature via regulation of FLC in Arabidopsis.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"5098","lastPage":"5098","volume":"5"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE","INDUCTION BY ELEVATED TEMPERATURES"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF116527","properties":[{"key":"ProteinId","value":"AAD21248.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF116528","properties":[{"key":"ProteinId","value":"AAD21249.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL356332","properties":[{"key":"ProteinId","value":"CAB92055.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"AED91498.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408687","properties":[{"key":"ProteinId","value":"CAO7051730.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"T50018","properties":[{"key":"EntryName","value":"T50018"}]},{"database":"RefSeq","id":"NP_196576.1","properties":[{"key":"NucleotideSequenceId","value":"NM_121052.3"}],"isoformId":"Q9S7Q7-1"},{"database":"AlphaFoldDB","id":"Q9S7Q7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9S7Q7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"16156","properties":[{"key":"Interactions","value":"13"}]},{"database":"DIP","id":"DIP-51640N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9S7Q7","properties":[{"key":"Number of interactors","value":"21"}]},{"database":"IntAct","id":"Q9S7Q7","properties":[{"key":"Interactions","value":"7"}]},{"database":"STRING","id":"3702.Q9S7Q7","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q9S7Q7","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"830878","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT5G10140","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT5G10140","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT5G10140","properties":[{"key":"GeneName","value":"FLC"}]},{"database":"eggNOG","id":"KOG0014","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_053053_0_4_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9S7Q7","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"INHTEYT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"1898716at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9S7Q7","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9S7Q7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"ExpressionAtlas","id":"Q9S7Q7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16623882"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16600915"}]},{"database":"GO","id":"GO:0046983","properties":[{"key":"GoTerm","value":"F:protein dimerization activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IPI:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"30356219"}]},{"database":"GO","id":"GO:0009910","properties":[{"key":"GoTerm","value":"P:negative regulation of flower development"},{"key":"GoEvidenceType","value":"IMP:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12114624"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042752","properties":[{"key":"GoTerm","value":"P:regulation of circadian rhythm"},{"key":"GoEvidenceType","value":"IMP:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16473970"}]},{"database":"GO","id":"GO:2000028","properties":[{"key":"GoTerm","value":"P:regulation of photoperiodism, flowering"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25267112"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0009266","properties":[{"key":"GoTerm","value":"P:response to temperature stimulus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25267112"}]},{"database":"GO","id":"GO:0010048","properties":[{"key":"GoTerm","value":"P:vernalization response"},{"key":"GoEvidenceType","value":"IEP:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"15734903"}]},{"database":"CDD","id":"cd00265","properties":[{"key":"EntryName","value":"MADS_MEF2_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.1810.10:FF:000020","properties":[{"key":"EntryName","value":"MADS-box protein FLOWERING LOCUS C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1810.10","properties":[{"key":"EntryName","value":"Transcription factor, MADS-box"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050142","properties":[{"key":"EntryName","value":"MADS-box/MEF2_TF"}]},{"database":"InterPro","id":"IPR033896","properties":[{"key":"EntryName","value":"MEF2-like_N"}]},{"database":"InterPro","id":"IPR002487","properties":[{"key":"EntryName","value":"TF_Kbox"}]},{"database":"InterPro","id":"IPR002100","properties":[{"key":"EntryName","value":"TF_MADSbox"}]},{"database":"InterPro","id":"IPR036879","properties":[{"key":"EntryName","value":"TF_MADSbox_sf"}]},{"database":"PANTHER","id":"PTHR48019","properties":[{"key":"EntryName","value":"SERUM RESPONSE FACTOR HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01486","properties":[{"key":"EntryName","value":"K-box"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00319","properties":[{"key":"EntryName","value":"SRF-TF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00404","properties":[{"key":"EntryName","value":"MADSDOMAIN"}]},{"database":"SMART","id":"SM00432","properties":[{"key":"EntryName","value":"MADS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55455","properties":[{"key":"EntryName","value":"SRF-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51297","properties":[{"key":"EntryName","value":"K_BOX"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00350","properties":[{"key":"EntryName","value":"MADS_BOX_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50066","properties":[{"key":"EntryName","value":"MADS_BOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGRKKLEIKRIENKSSRQVTFSKRRNGLIEKARQLSVLCDASVALLVVSASGKLYSFSSGDNLVKILDRYGKQHADDLKALDHQSKALNYGSHYELLELVDSKLVGSNVKNVSIDALVQLEEHLETALSVTRAKKTELMLKLVENLKEKEKMLKEENQVLASQMENNHHVGAEAEMEMSPAGQISDNLPVTLPLLN","length":196,"molWeight":21865,"crc64":"656085A2B157FF42","md5":"FD80D3157704C71C9FED7B18B0983286"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"INDUCTION":1,"DISRUPTION PHENOTYPE":1,"MISCELLANEOUS":1},"countByFeatureType":{"Chain":1,"Domain":2,"Motif":1},"uniParcId":"UPI0000001729"}}