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MCM2 · P49736

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Meet the protein

MCM2 is UniProt protein record P49736 for Homo sapiens (NCBI 9606). The retained sequence contains 904 amino acids.

[1]
Evidence for this statement

Source annotation

What is known about function

Function and evidence from UniProt

Inspect structured data
source text
Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677)
source language
en
evidence codes
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    26196677
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    32453425
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    34694004
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    34700328
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    35585232
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    8175912
[1]
Evidence for this statement

Source annotation

Evidence codes qualify the annotation. This record is not a measurement of an illustrated specimen.

Sequence and version

P49736

Inspect structured data
accession
P49736
name
DNA replication licensing factor MCM2
length
904
entry version
249
sequence version
4
sequence
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTE
GPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQR
DREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGH
SVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAR
EHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQL
HLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGP
FEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHN
NYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFAS
IAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVS
SRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSI
HEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDIL
CVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVL
KKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARI
HLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLV
AEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMI
LQQF
[1]
Evidence for this statement

Source annotation

Genes and domains

Cross-references supplied by UniProt

Inspect structured data
gene symbols
  • MCM2
gene crossreferences
  • database
    Ensembl
    id
    ENST00000265056.12
    properties
    • key
      ProteinId
      value
      ENSP00000265056.7
    • key
      GeneId
      value
      ENSG00000073111.16
  • database
    GeneID
    id
    4171
    properties
    • key
      Description
      value
      -
interpro domains
  • provider
    interpro
    accession
    IPR031327
    name
    MCM
  • provider
    interpro
    accession
    IPR008045
    name
    MCM2
  • provider
    interpro
    accession
    IPR061506
    name
    MCM2_N
  • provider
    interpro
    accession
    IPR018525
    name
    MCM_CS
  • provider
    interpro
    accession
    IPR001208
    name
    MCM_dom
  • provider
    interpro
    accession
    IPR041562
    name
    MCM_lid
  • provider
    interpro
    accession
    IPR027925
    name
    MCM_N
  • provider
    interpro
    accession
    IPR033762
    name
    MCM_OB
  • provider
    interpro
    accession
    IPR012340
    name
    NA-bd_OB-fold
  • provider
    interpro
    accession
    IPR027417
    name
    P-loop_NTPase
  • provider
    interpro
    accession
    IPR059098
    name
    WHD_MCM2
[1]
Evidence for this statement

Source annotation

GO function annotations

A sample with evidence codes

Inspect structured data

Shown / materialized / in provider response: 12 / 126 / 126

GO
GOEvidencePublication or ruleAssigned by
GO:0005730
nucleolus
Cellular Component		ECO:0000314
NOT|located_in		PMID:21383955UniProt
20170426
GO:0017116
single-stranded DNA helicase activity
Molecular Function		ECO:0000318
contributes_to		GO_REF:0000033GO_Central
20210414
GO:0043138
3'-5' DNA helicase activity
Molecular Function		ECO:0000318
contributes_to		GO_REF:0000033GO_Central
20190210
GO:0003677
DNA binding
Molecular Function		ECO:0000256
enables		GO_REF:0000002InterPro
20260727
GO:0003677
DNA binding
Molecular Function		ECO:0000304
enables		PMID:8175912PINC
20030904
GO:0003678
DNA helicase activity
Molecular Function		ECO:0000501
enables		GO_REF:0000120UniProt
20260727
GO:0003688
DNA replication origin binding
Molecular Function		ECO:0000265
enables		GO_REF:0000107Ensembl
20260724
GO:0003697
single-stranded DNA binding
Molecular Function		ECO:0000318
enables		GO_REF:0000033GO_Central
20230110
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:11095689UniProt
20070220
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:12740381IntAct
20260725
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:15232106IntAct
20260725
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:15232106IntAct
20260725
[2] [3]
Evidence for this statement

Source annotation

These are source annotations, not independent proof of a causal mechanism. The complete captured responses are available as originals.

Research cited by the protein record

Bibliographic records

Inspect structured data
  • source
    uniprot
    id
    P49736-citation-8175912
    title
    A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division.
    pmid
    8175912
    doi
    10.1242/jcs.107.1.253
    year
    1994
    authors
    • Todorov I.T.
    • Pepperkok R.
    • Philipova R.N.
    • Kearsey S.E.
    • Ansorge W.
    • Werner D.
    journal
    J. Cell Sci.
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/P49736.json
    source snapshot sha256
    6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
  • source
    uniprot
    id
    P49736-citation-7584026
    title
    Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.
    pmid
    7584026
    doi
    10.1093/dnares/1.1.27
    year
    1994
    authors
    • Nomura N.
    • Miyajima N.
    • Sazuka T.
    • Tanaka A.
    • Kawarabayasi Y.
    • Sato S.
    • Nagase T.
    • Seki N.
    • Ishikawa K.
    • Tabata S.
    journal
    DNA Res.
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/P49736.json
    source snapshot sha256
    6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
  • source
    uniprot
    id
    P49736-citation-15489334
    title
    The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
    pmid
    15489334
    doi
    10.1101/gr.2596504
    year
    2004
    authors
      journal
      Genome Res.
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/P49736.json
      source snapshot sha256
      6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
    • source
      uniprot
      id
      P49736-citation-CI-D7CASS6KHIPA6
      title
      Homo sapiens DNA replication licensing factor (huMCM2).
      pmid
      —
      doi
      —
      year
      MAR-
      authors
      • Mimura S.
      • Nishimoto S.
      • Kubota Y.
      • Takisawa H.
      • Nojima H.
      journal
      —
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/P49736.json
      source snapshot sha256
      6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
    • source
      uniprot
      id
      P49736-citation-CI-4IUTBOVVGSAD8
      title
      Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
      pmid
      —
      doi
      —
      year
      AUG-
      authors
      • Kalnine N.
      • Chen X.
      • Rolfs A.
      • Halleck A.
      • Hines L.
      • Eisenstein S.
      • Koundinya M.
      • Raphael J.
      • Moreira D.
      • Kelley T.
      • LaBaer J.
      • Lin Y.
      • Phelan M.
      • Farmer A.
      journal
      —
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/P49736.json
      source snapshot sha256
      6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
    • source
      uniprot
      id
      P49736-citation-8258304
      title
      The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21.
      pmid
      8258304
      doi
      10.1159/000133647
      year
      1994
      authors
      • Mincheva A.
      • Todorov I.T.
      • Werner D.
      • Fink T.M.
      • Lichter P.
      journal
      Cytogenet. Cell Genet.
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/P49736.json
      source snapshot sha256
      6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
    • source
      uniprot
      id
      P49736-citation-9305914
      title
      A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
      pmid
      9305914
      doi
      10.1074/jbc.272.39.24508
      year
      1997
      authors
      • Ishimi Y.
      journal
      J. Biol. Chem.
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/P49736.json
      source snapshot sha256
      6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
    • source
      uniprot
      id
      P49736-citation-11095689
      title
      The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.
      pmid
      11095689
      doi
      10.1093/nar/28.23.4769
      year
      2000
      authors
      • Izumi M.
      • Yanagi K.
      • Mizuno T.
      • Yokoi M.
      • Kawasaki Y.
      • Moon K.Y.
      • Hurwitz J.
      • Yatagai F.
      • Hanaoka F.
      journal
      Nucleic Acids Res.
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/P49736.json
      source snapshot sha256
      6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
    • source
      uniprot
      id
      P49736-citation-15210935
      title
      Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.
      pmid
      15210935
      doi
      10.1073/pnas.0403410101
      year
      2004
      authors
      • Cortez D.
      • Glick G.
      • Elledge S.J.
      journal
      Proc. Natl. Acad. Sci. U.S.A.
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/P49736.json
      source snapshot sha256
      6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
    • source
      uniprot
      id
      P49736-citation-17081983
      title
      Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
      pmid
      17081983
      doi
      10.1016/j.cell.2006.09.026
      year
      2006
      authors
      • Olsen J.V.
      • Blagoev B.
      • Gnad F.
      • Macek B.
      • Kumar C.
      • Mortensen P.
      • Mann M.
      journal
      Cell
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/P49736.json
      source snapshot sha256
      6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
    • source
      uniprot
      id
      P49736-citation-16899510
      title
      Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.
      pmid
      16899510
      doi
      10.1091/mbc.e06-03-0241
      year
      2006
      authors
      • Tsuji T.
      • Ficarro S.B.
      • Jiang W.
      journal
      Mol. Biol. Cell
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/P49736.json
      source snapshot sha256
      6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
    • source
      uniprot
      id
      P49736-citation-16387653
      title
      ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
      pmid
      16387653
      doi
      10.1016/j.molcel.2005.12.007
      year
      2006
      authors
      • Doyon Y.
      • Cayrou C.
      • Ullah M.
      • Landry A.-J.
      • Cote V.
      • Selleck W.
      • Lane W.S.
      • Tan S.
      • Yang X.-J.
      • Cote J.
      journal
      Mol. Cell
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/P49736.json
      source snapshot sha256
      6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
    [1]
    Evidence for this statement

    Source annotation

    Only metadata is shown. Article text has a separate reuse decision.

    Organism in the UniProt record

    Homo sapiens · NCBI 9606Scientific profile →

    Your research question

    Save the article to return to your question and this source version.

    Plan a test

    This is your research plan. Completing these fields does not confirm a hypothesis.

    Sources and versions

    An explanation grounded in the cited sources

    1. UniProt Consortium · P49736

      2026-09-09T03:19:37.652260+00:00 · CC-BY-4.0

      Provenance and original
      Source version
      entry 249; sequence 4
      Original SHA-256
      6d1b85a1e548c32f74248e487f6817342ecc7e523b6a7933520c9700d188356f
      Processing
      Unmodified provider response; selected fields are projected into the document.
      Version details
      Native entry and sequence versions retained.

      View original JSON · Download original

    2. Gene Ontology Consortium / QuickGO · UniProtKB:P49736

      2026-09-09T03:19:38.868150+00:00 · CC-BY-4.0

      Provenance and original
      Original SHA-256
      03e6f92c3168330f8946e992b513d8ce36cb88cc515fb8b994786586182c74a4
      Processing
      Unmodified provider response; selected fields are projected into the document.
      Version details
      No native GO release was supplied; exact response hash and retrieval time are retained.

      View original JSON · Download original

    3. Gene Ontology Consortium / QuickGO · UniProtKB:P49736

      2026-09-09T03:19:39.500632+00:00 · CC-BY-4.0

      Provenance and original
      Original SHA-256
      f04c287bd242718906bc146fd64c51d2efb2c5a3e215f77414c83d78350af922
      Processing
      Unmodified provider response; selected fields are projected into the document.
      Version details
      No native GO release was supplied; exact response hash and retrieval time are retained.

      View original JSON · Download original

    Inspect structured data
    Content version
    c440ca2667559f68702ce349d0e8c5d825ca6125e7bc68dad2eccd3e415e4646
    Source version
    research-20260909.1
    Updated
    2026-09-09