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BRCA2 · P51587

In brief

BRCA2 is UniProt protein record P51587 for Homo sapiens (NCBI 9606). The retained sequence contains 3418 amino acids. [1]

Evidence for this statement

Source annotation

Where to check this statement

uniprot-P51587
Captured UniProt JSON: primaryAccession, organism, sequence and FUNCTION comments
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Editorial draft · human review pending

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Meet the protein

BRCA2 helps preserve genome integrity. UniProt describes its main role in homologous recombination, a process that repairs damaged DNA using a similar sequence. BRCA2 helps place RAD51 on single-stranded DNA at a damaged region. RAD51 performs strand exchange; BRCA2 helps establish the conditions in which RAD51 can work.

[1]
Evidence for this statement

Editorial synthesis

Where to check this statement

uniprot-P51587
Captured UniProt JSON: primaryAccession, organism, sequence and FUNCTION comments

DNA repair involves several interacting proteins. UniProt describes BRCA2 helping assemble and stabilize RAD51 on DNA and connects individual statements to publications. Compare this explanation with the original annotation, evidence codes and sequence below. These data describe the selected human entry P51587; they do not automatically establish the function of every sequence variant.

[1]
Evidence for this statement

Editorial synthesis

Where to check this statement

uniprot-P51587
Captured UniProt JSON: primaryAccession, organism, sequence and FUNCTION comments

Repair depends on organised strand exchange

After a DNA break, a damaged region must be connected with a suitable homologous sequence. BRCA2 helps assemble RAD51 on single-stranded DNA and stabilise the resulting filament; RAD51 then carries out strand exchange. The retained UniProt annotation also links BRCA2 to replication-associated and meiotic contexts. This is why one protein can connect different genome-maintenance questions. Its full sequence, interacting partners and the evidence for each function provide complementary information.

[1]
Evidence for this statement

EcoGenesis

Where to check this statement

uniprot-P51587
Retained UniProt JSON: comments[commentType=FUNCTION], selected accession and entry version as recorded in evidence

Teaching diagram

Evidence for this statement

EcoGenesis

    Original teaching diagram of the relationship described in the retained FUNCTION annotation; no measured rate, geometry or experimental result is shown.
    1. Damaged DNA

      The repair substrate

    2. BRCA2 and RAD51

      Assembly and stabilisation

    3. Strand exchange

      RAD51-mediated step

    • Damaged DNA → BRCA2 and RAD51: connects with
    • BRCA2 and RAD51 → Strand exchange: connects with

    What is known about function

    Function and evidence from UniProt

    Inspect structured data
    Source text
    Tumor suppressor protein that maintains genome stability primarily by repairing damaged DNA through homologous recombination (HR) (PubMed:11239456, PubMed:12442171, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:15937124, PubMed:17515903, PubMed:17515904, PubMed:18317453, PubMed:19303847, PubMed:20729832, PubMed:20729858, PubMed:20729859, PubMed:21719596, PubMed:27941124, PubMed:37499663, PubMed:37515771). Facilitates the repair of double-strand breaks (DSBs) by binding and mediating the loading of the RAD51 protein onto single-stranded DNA (ssDNA), thereby promoting the activity of RAD51, which catalyzes DNA strand exchange (PubMed:11239456, PubMed:12442171, PubMed:15937124, PubMed:17515903, PubMed:17515904, PubMed:18317453, PubMed:19303847, PubMed:20729832, PubMed:20729858, PubMed:20729859, PubMed:27941124, PubMed:37499663). BRCA2 nucleates and stabilizes RAD51 on ssDNA directly and delivers RAD51 to ssDNA-double-stranded DNA (dsDNA) junctions by sliding along dsDNA backbone (PubMed:12442171, PubMed:19303847, PubMed:37499663). RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilization of RAD51-ssDNA filaments by blocking ATP hydrolysis (PubMed:20729859). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). Required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability (PubMed:24896180). Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). Also promotes RAD51 loading to telomeric regions, facilitating telomere replication and capping (PubMed:21076401). Also required for homologous recombination during meiosis by promoting the recruitment of RAD51 and DMC1 recombinases to meiotic DSB sites, enabling proper chromosome pairing and crossing over (PubMed:26976601). Also promotes homologous recombination by inactivating the FIGNL1-FIRRM complex to protect RAD51 filament from premature disassembly (PubMed:37515771). Together with NPM1, may also regulate centrosome duplication (PubMed:21084279)
    Source language
    en
    evidence codes
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      11239456
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      12442171
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      15115758
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      15199141
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      15671039
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      15937124
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      17515903
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      17515904
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      18317453
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      19303847
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      20729832
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      20729858
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      20729859
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      21076401
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      21084279
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      21719596
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      24485656
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      24896180
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      26976601
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      27941124
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      37499663
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      37515771
    [1]
    Evidence for this statement

    Source annotation

    Where to check this statement

    uniprot-P51587
    Captured UniProt JSON: comments[commentType=FUNCTION] and attached evidence codes

    Evidence codes qualify the annotation. This record is not a measurement of an illustrated specimen.

    Sequence and version

    P51587

    Inspect structured data
    accession
    P51587
    name
    Breast cancer type 2 susceptibility protein
    length
    3418
    entry version
    252
    sequence version
    4
    Sequence
    MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPN
LFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTV
KTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHI
SESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESL
KKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVV
DTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEP
NDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCD
QNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDC
ILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGL
EIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSY
KGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLT
SSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCEND
PKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLS
NLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYM
RVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNN
LALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVK
QHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLS
EHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSD
CKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKS
TFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDC
NKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISL
SSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENE
DNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQI
KEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAK
ESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTG
NQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFS
HQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNL
CRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTS
VSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYL
SNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAY
PQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIK
KVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKV
FADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFST
ASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLI
SQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQ
NVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQ
DKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSE
NYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILV
GEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKE
RQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTG
RPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKN
NSNQAVAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPR
ISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQ
LADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPK
EFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANI
SETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVG
SPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDV
IIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENT
TKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKK
QAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLL
TEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKF
LDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLI
AASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKL
MHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSV
STPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQP
PRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEK
QFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI
    [1]
    Evidence for this statement

    Source annotation

    Where to check this statement

    uniprot-P51587
    Captured UniProt JSON: sequence.value, sequence.length, sequenceVersion and entryVersion

    Genes and domains

    Cross-references supplied by UniProt

    Inspect structured data
    gene symbols
    • BRCA2
    gene crossreferences
    • database
      Ensembl
      id
      ENST00000380152.8
      properties
      • key
        ProteinId
        value
        ENSP00000369497.3
      • key
        GeneId
        value
        ENSG00000139618.19
    • database
      Ensembl
      id
      ENST00000544455.6
      properties
      • key
        ProteinId
        value
        ENSP00000439902.1
      • key
        GeneId
        value
        ENSG00000139618.19
    • database
      Ensembl
      id
      ENST00000680887.1
      properties
      • key
        ProteinId
        value
        ENSP00000505508.1
      • key
        GeneId
        value
        ENSG00000139618.19
    • database
      GeneID
      id
      675
      properties
      • key
        Description
        value
        -
    interpro domains
    • Provider
      interpro
      accession
      IPR015525
      name
      BRCA2
    • Provider
      interpro
      accession
      IPR015252
      name
      BRCA2_hlx
    • Provider
      interpro
      accession
      IPR036315
      name
      BRCA2_hlx_sf
    • Provider
      interpro
      accession
      IPR015187
      name
      BRCA2_OB_1
    • Provider
      interpro
      accession
      IPR048262
      name
      BRCA2_OB_2_dom
    • Provider
      interpro
      accession
      IPR015188
      name
      BRCA2_OB_3
    • Provider
      interpro
      accession
      IPR002093
      name
      BRCA2_repeat
    • Provider
      interpro
      accession
      IPR055077
      name
      BRCA2_TR2
    • Provider
      interpro
      accession
      IPR012340
      name
      NA-bd_OB-fold
    • Provider
      interpro
      accession
      IPR015205
      name
      Tower_dom
    [1]
    Evidence for this statement

    Source annotation

    Where to check this statement

    uniprot-P51587
    Captured UniProt JSON: genes, features and cross-references

    GO function annotations

    A sample with evidence codes

    Inspect structured data

    Shown / materialized / in provider response: 12 / 169 / 169

    GO
    GOEvidencePublication or ruleAssigned by
    GO:0004402
    histone acetyltransferase activity
    Molecular Function    		ECO:0000314
    NOT|enables    		PMID:9824164UniProt
    20060718
    GO:0002020
    protease binding
    Molecular Function    		ECO:0000353
    enables    		PMID:15314155UniProt
    20100604
    GO:0003690
    double-stranded DNA binding
    Molecular Function    		ECO:0000314
    enables    		PMID:37499663UniProt
    20260302
    GO:0003697
    single-stranded DNA binding
    Molecular Function    		ECO:0000318
    enables    		GO_REF:0000033GO_Central
    20250320
    GO:0003697
    single-stranded DNA binding
    Molecular Function    		ECO:0000314
    enables    		PMID:20729832UniProt
    20101006
    GO:0003697
    single-stranded DNA binding
    Molecular Function    		ECO:0000314
    enables    		PMID:37499663UniProt
    20260302
    GO:0005515
    protein binding
    Molecular Function    		ECO:0000353
    enables    		PMID:10373512UniProt
    20070807
    GO:0005515
    protein binding
    Molecular Function    		ECO:0000353
    enables    		PMID:10373512IntAct
    20260725
    GO:0005515
    protein binding
    Molecular Function    		ECO:0000353
    enables    		PMID:10551859IntAct
    20260725
    GO:0005515
    protein binding
    Molecular Function    		ECO:0000353
    enables    		PMID:11597317UniProt
    20070807
    GO:0005515
    protein binding
    Molecular Function    		ECO:0000353
    enables    		PMID:12242698UniProt
    20090624
    GO:0005515
    protein binding
    Molecular Function    		ECO:0000353
    enables    		PMID:12242698UniProt
    20070807
    [2] [3]
    Evidence for this statement

    Source annotation

    Where to check this statement

    quickgo-P51587-1
    Captured QuickGO annotation results: GO ID, qualifier, evidenceCode, reference, assignedBy and date; limited returned pages
    quickgo-P51587-2
    Captured QuickGO annotation results: GO ID, qualifier, evidenceCode, reference, assignedBy and date; limited returned pages

    These are source annotations, not independent proof of a causal mechanism. The complete captured responses are available as originals.

    Research cited by the protein record

    Bibliographic records

    Inspect structured data
    • Source
      uniprot
      id
      P51587-citation-8524414
      title
      Identification of the breast cancer susceptibility gene BRCA2.
      pmid
      8524414
      doi
      10.1038/378789a0
      year
      1995
      authors
      • Wooster R.
      • Bignell G.
      • Lancaster J.
      • Swift S.
      • Seal S.
      • Mangion J.
      • Collins N.
      • Gregory S.
      • Gumbs C.
      • Micklem G.
      • Barfoot R.
      • Hamoudi R.
      • Patel S.
      • Rice C.
      • Biggs P.
      • Hashim Y.
      • Smith A.
      • Connor F.
      • Arason A.
      • Gudmundsson J.
      • Ficenec D.
      • Kelsell D.
      • Ford D.
      • Tonin P.
      • Bishop D.T.
      • Spurr N.K.
      • Ponder B.A.J.
      • Eeles R.
      • Peto J.
      • Devilee P.
      • Cornelisse C.
      • Lynch H.
      • Narod S.
      • Lenoir G.
      • Egilsson V.
      • Barkadottir R.B.
      • Easton D.F.
      • Bentley D.R.
      • Futreal P.A.
      • Ashworth A.
      • Stratton M.R.
      journal
      Nature
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    • Source
      uniprot
      id
      P51587-citation-8589730
      title
      The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
      pmid
      8589730
      doi
      10.1038/ng0396-333
      year
      1996
      authors
      • Tavtigian S.V.
      • Simard J.
      • Rommens J.
      • Couch F.
      • Shattuck-Eidens D.
      • Neuhausen S.
      • Merajver S.
      • Thorlacius S.
      • Offit K.
      • Stoppa-Lyonnet D.
      • Belanger C.
      • Bell R.
      • Berry S.
      • Bogden R.
      • Chen Q.
      • Davis T.
      • Dumont M.
      • Frye C.
      • Hattier T.
      • Jammulapati S.
      • Janecki T.
      • Jiang P.
      • Kehrer R.
      • Leblanc J.-F.
      • Mitchell J.T.
      • McArthur-Morrison J.
      • Nguyen K.
      • Peng Y.
      • Samson C.
      • Schroeder M.
      • Snyder S.C.
      • Steele L.
      • Stringfellow M.
      • Stroup C.
      • Swedlund B.
      • Swensen J.
      • Teng D.
      • Thomas A.
      • Tran T.
      • Tran T.
      • Tranchant M.
      • Weaver-Feldhaus J.
      • Wong A.K.C.
      • Shizuya H.
      • Eyfjord J.E.
      • Cannon-Albright L.
      • Labrie F.
      • Skolnick M.H.
      • Weber B.
      • Kamb A.
      • Goldar D.E.
      journal
      Nat. Genet.
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    • Source
      uniprot
      id
      P51587-citation-15057823
      title
      The DNA sequence and analysis of human chromosome 13.
      pmid
      15057823
      doi
      10.1038/nature02379
      year
      2004
      authors
      • Dunham A.
      • Matthews L.H.
      • Burton J.
      • Ashurst J.L.
      • Howe K.L.
      • Ashcroft K.J.
      • Beare D.M.
      • Burford D.C.
      • Hunt S.E.
      • Griffiths-Jones S.
      • Jones M.C.
      • Keenan S.J.
      • Oliver K.
      • Scott C.E.
      • Ainscough R.
      • Almeida J.P.
      • Ambrose K.D.
      • Andrews D.T.
      • Ashwell R.I.S.
      • Babbage A.K.
      • Bagguley C.L.
      • Bailey J.
      • Bannerjee R.
      • Barlow K.F.
      • Bates K.
      • Beasley H.
      • Bird C.P.
      • Bray-Allen S.
      • Brown A.J.
      • Brown J.Y.
      • Burrill W.
      • Carder C.
      • Carter N.P.
      • Chapman J.C.
      • Clamp M.E.
      • Clark S.Y.
      • Clarke G.
      • Clee C.M.
      • Clegg S.C.
      • Cobley V.
      • Collins J.E.
      • Corby N.
      • Coville G.J.
      • Deloukas P.
      • Dhami P.
      • Dunham I.
      • Dunn M.
      • Earthrowl M.E.
      • Ellington A.G.
      • Faulkner L.
      • Frankish A.G.
      • Frankland J.
      • French L.
      • Garner P.
      • Garnett J.
      • Gilbert J.G.R.
      • Gilson C.J.
      • Ghori J.
      • Grafham D.V.
      • Gribble S.M.
      • Griffiths C.
      • Hall R.E.
      • Hammond S.
      • Harley J.L.
      • Hart E.A.
      • Heath P.D.
      • Howden P.J.
      • Huckle E.J.
      • Hunt P.J.
      • Hunt A.R.
      • Johnson C.
      • Johnson D.
      • Kay M.
      • Kimberley A.M.
      • King A.
      • Laird G.K.
      • Langford C.J.
      • Lawlor S.
      • Leongamornlert D.A.
      • Lloyd D.M.
      • Lloyd C.
      • Loveland J.E.
      • Lovell J.
      • Martin S.
      • Mashreghi-Mohammadi M.
      • McLaren S.J.
      • McMurray A.
      • Milne S.
      • Moore M.J.F.
      • Nickerson T.
      • Palmer S.A.
      • Pearce A.V.
      • Peck A.I.
      • Pelan S.
      • Phillimore B.
      • Porter K.M.
      • Rice C.M.
      • Searle S.
      • Sehra H.K.
      • Shownkeen R.
      • Skuce C.D.
      • Smith M.
      • Steward C.A.
      • Sycamore N.
      • Tester J.
      • Thomas D.W.
      • Tracey A.
      • Tromans A.
      • Tubby B.
      • Wall M.
      • Wallis J.M.
      • West A.P.
      • Whitehead S.L.
      • Willey D.L.
      • Wilming L.
      • Wray P.W.
      • Wright M.W.
      • Young L.
      • Coulson A.
      • Durbin R.M.
      • Hubbard T.
      • Sulston J.E.
      • Beck S.
      • Bentley D.R.
      • Rogers J.
      • Ross M.T.
      journal
      Nature
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    • Source
      uniprot
      id
      P51587-citation-7658781
      title
      Linkage to BRCA2 region in hereditary male breast cancer.
      pmid
      7658781
      doi
      10.1016/s0140-6736(95)91383-1
      year
      1995
      authors
      • Thorlacius S.
      • Tryggvadottir L.
      • Olafsdottir G.H.
      • Jonasson J.G.
      • Ogmundsdottir H.M.
      • Tulinius H.
      • Eyfjord J.E.
      journal
      Lancet
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    • Source
      uniprot
      id
      P51587-citation-9150155
      title
      Study of a single BRCA2 mutation with high carrier frequency in a small population.
      pmid
      9150155
      doi
      —
      year
      1997
      authors
      • Thorlacius S.
      • Sigurdsson S.
      • Bjarnadottir H.
      • Olafsdottir G.
      • Jonasson J.G.
      • Tryggvadottir L.
      • Tulinius H.
      • Eyfjoerd J.E.
      journal
      Am. J. Hum. Genet.
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    • Source
      uniprot
      id
      P51587-citation-9140390
      title
      Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients.
      pmid
      9140390
      doi
      10.1038/ng0597-17
      year
      1997
      authors
      • Ozcelik H.
      • Schmocker B.
      • Di Nicola N.
      • Shi X.H.
      • Langer B.
      • Moore M.
      • Taylor B.R.
      • Narod S.A.
      • Darlington G.
      • Andrulis I.L.
      • Gallinger S.
      • Redston M.
      journal
      Nat. Genet.
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    • Source
      uniprot
      id
      P51587-citation-10584720
      title
      Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2.
      pmid
      10584720
      doi
      10.1016/s0140-6736(99)04336-6
      year
      1999
      authors
      • Jernstroem H.
      • Lerman C.
      • Ghadirian P.
      • Lynch H.T.
      • Weber B.
      • Garber J.
      • Daly M.
      • Olopade O.I.
      • Foulkes W.D.
      • Warner E.
      • Brunet J.S.
      • Narod S.A.
      journal
      Lancet
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    • Source
      uniprot
      id
      P51587-citation-10373512
      title
      Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.
      pmid
      10373512
      doi
      10.1128/mcb.19.7.4633
      year
      1999
      authors
      • Marston N.J.
      • Richards W.J.
      • Hughes D.
      • Bertwistle D.
      • Marshall C.J.
      • Ashworth A.
      journal
      Mol. Cell. Biol.
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    • Source
      uniprot
      id
      P51587-citation-11158174
      title
      De novo recurrent germline mutation of the BRCA2 gene in a patient with early onset breast cancer.
      pmid
      11158174
      doi
      10.1136/jmg.38.2.102
      year
      2001
      authors
      • van der Luijt R.B.
      • van Zon P.H.
      • Jansen R.P.
      • van der Sijs-Bos C.J.
      • Warlam-Rodenhuis C.C.
      • Ausems M.G.
      journal
      J. Med. Genet.
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    • Source
      uniprot
      id
      P51587-citation-11239456
      title
      Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.
      pmid
      11239456
      doi
      10.1016/s1097-2765(01)00175-7
      year
      2001
      authors
      • Davies A.A.
      • Masson J.Y.
      • McIlwraith M.J.
      • Stasiak A.Z.
      • Stasiak A.
      • Venkitaraman A.R.
      • West S.C.
      journal
      Mol. Cell
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    • Source
      uniprot
      id
      P51587-citation-15115758
      title
      Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.
      pmid
      15115758
      doi
      10.1093/hmg/ddh135
      year
      2004
      authors
      • Hussain S.
      • Wilson J.B.
      • Medhurst A.L.
      • Hejna J.
      • Witt E.
      • Ananth S.
      • Davies A.
      • Masson J.-Y.
      • Moses R.
      • West S.C.
      • de Winter J.P.
      • Ashworth A.
      • Jones N.J.
      • Mathew C.G.
      journal
      Hum. Mol. Genet.
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    • Source
      uniprot
      id
      P51587-citation-15199141
      title
      Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.
      pmid
      15199141
      doi
      10.1128/mcb.24.13.5850-5862.2004
      year
      2004
      authors
      • Wang X.Z.
      • Andreassen P.R.
      • D'Andrea A.D.
      journal
      Mol. Cell. Biol.
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/P51587.json
      Source snapshot SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    [1]
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    uniprot-P51587
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    1. UniProt Consortium · P51587

      2026-09-09T03:19:37.686498+00:00 · CC-BY-4.0

      Provenance and original
      Source version
      entry 252; sequence 4
      Original SHA-256
      befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
      Processing
      Unmodified provider response; selected fields are projected into the document.
      Version details
      Native entry and sequence versions retained.

      View original JSON · Download original

    2. Gene Ontology Consortium / QuickGO · UniProtKB:P51587

      2026-09-09T03:19:39.004762+00:00 · CC-BY-4.0

      Provenance and original
      Original SHA-256
      362e66f46f82c372fb8fc92bb3842b46320fbae8eae85d9497bd550ae9211404
      Processing
      Unmodified provider response; selected fields are projected into the document.
      Version details
      No native GO release was supplied; exact response hash and retrieval time are retained.

      View original JSON · Download original

    3. Gene Ontology Consortium / QuickGO · UniProtKB:P51587

      2026-09-09T03:19:40.324061+00:00 · CC-BY-4.0

      Provenance and original
      Original SHA-256
      f4d7f8c2a54ea95b803629bb8d105b0794cf2d6d68e14ac4e03e501eebeb0594
      Processing
      Unmodified provider response; selected fields are projected into the document.
      Version details
      No native GO release was supplied; exact response hash and retrieval time are retained.

      View original JSON · Download original

    Inspect structured data
    Content version
    86ac29c9a8dddf1e8aad8c3beab615ec170a2602396a249b7e751c6ea93570d2
    Source version
    research-20260909.1
    Updated
    2026-10-01