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BRCA2 · P51587

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Знакомство с белком

BRCA2 — белковая запись P51587 из UniProt для Homo sapiens (NCBI 9606). В сохранённой версии последовательность содержит 3418 аминокислот.

[1]
Основание утверждения

Аннотация источника

Что известно о функции

Функция: текст и доказательства UniProt (EN)

Посмотреть структурированные данные
source text
Tumor suppressor protein that maintains genome stability primarily by repairing damaged DNA through homologous recombination (HR) (PubMed:11239456, PubMed:12442171, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:15937124, PubMed:17515903, PubMed:17515904, PubMed:18317453, PubMed:19303847, PubMed:20729832, PubMed:20729858, PubMed:20729859, PubMed:21719596, PubMed:27941124, PubMed:37499663, PubMed:37515771). Facilitates the repair of double-strand breaks (DSBs) by binding and mediating the loading of the RAD51 protein onto single-stranded DNA (ssDNA), thereby promoting the activity of RAD51, which catalyzes DNA strand exchange (PubMed:11239456, PubMed:12442171, PubMed:15937124, PubMed:17515903, PubMed:17515904, PubMed:18317453, PubMed:19303847, PubMed:20729832, PubMed:20729858, PubMed:20729859, PubMed:27941124, PubMed:37499663). BRCA2 nucleates and stabilizes RAD51 on ssDNA directly and delivers RAD51 to ssDNA-double-stranded DNA (dsDNA) junctions by sliding along dsDNA backbone (PubMed:12442171, PubMed:19303847, PubMed:37499663). RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilization of RAD51-ssDNA filaments by blocking ATP hydrolysis (PubMed:20729859). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). Required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability (PubMed:24896180). Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). Also promotes RAD51 loading to telomeric regions, facilitating telomere replication and capping (PubMed:21076401). Also required for homologous recombination during meiosis by promoting the recruitment of RAD51 and DMC1 recombinases to meiotic DSB sites, enabling proper chromosome pairing and crossing over (PubMed:26976601). Also promotes homologous recombination by inactivating the FIGNL1-FIRRM complex to protect RAD51 filament from premature disassembly (PubMed:37515771). Together with NPM1, may also regulate centrosome duplication (PubMed:21084279)
source language
en
evidence codes
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    11239456
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    12442171
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    15115758
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    15199141
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    15671039
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    15937124
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    17515903
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    17515904
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    18317453
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    19303847
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    20729832
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    20729858
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    20729859
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    21076401
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    21084279
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    21719596
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    24485656
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    24896180
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    26976601
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    27941124
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    37499663
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    37515771
[1]
Основание утверждения

Аннотация источника

Код доказательства относится к аннотации. Запись не является измерением изображённого организма.

Последовательность и версия

P51587

Посмотреть структурированные данные
accession
P51587
name
Breast cancer type 2 susceptibility protein
length
3418
entry version
252
sequence version
4
sequence
MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPN
LFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTV
KTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHI
SESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESL
KKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVV
DTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEP
NDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCD
QNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDC
ILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGL
EIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSY
KGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLT
SSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCEND
PKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLS
NLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYM
RVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNN
LALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVK
QHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLS
EHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSD
CKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKS
TFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDC
NKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISL
SSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENE
DNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQI
KEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAK
ESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTG
NQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFS
HQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNL
CRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTS
VSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYL
SNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAY
PQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIK
KVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKV
FADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFST
ASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLI
SQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQ
NVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQ
DKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSE
NYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILV
GEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKE
RQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTG
RPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKN
NSNQAVAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPR
ISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQ
LADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPK
EFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANI
SETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVG
SPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDV
IIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENT
TKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKK
QAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLL
TEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKF
LDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLI
AASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKL
MHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSV
STPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQP
PRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEK
QFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI
[1]
Основание утверждения

Аннотация источника

Гены и домены

Связи, указанные UniProt

Посмотреть структурированные данные
gene symbols
  • BRCA2
gene crossreferences
  • database
    Ensembl
    id
    ENST00000380152.8
    properties
    • key
      ProteinId
      value
      ENSP00000369497.3
    • key
      GeneId
      value
      ENSG00000139618.19
  • database
    Ensembl
    id
    ENST00000544455.6
    properties
    • key
      ProteinId
      value
      ENSP00000439902.1
    • key
      GeneId
      value
      ENSG00000139618.19
  • database
    Ensembl
    id
    ENST00000680887.1
    properties
    • key
      ProteinId
      value
      ENSP00000505508.1
    • key
      GeneId
      value
      ENSG00000139618.19
  • database
    GeneID
    id
    675
    properties
    • key
      Description
      value
      -
interpro domains
  • provider
    interpro
    accession
    IPR015525
    name
    BRCA2
  • provider
    interpro
    accession
    IPR015252
    name
    BRCA2_hlx
  • provider
    interpro
    accession
    IPR036315
    name
    BRCA2_hlx_sf
  • provider
    interpro
    accession
    IPR015187
    name
    BRCA2_OB_1
  • provider
    interpro
    accession
    IPR048262
    name
    BRCA2_OB_2_dom
  • provider
    interpro
    accession
    IPR015188
    name
    BRCA2_OB_3
  • provider
    interpro
    accession
    IPR002093
    name
    BRCA2_repeat
  • provider
    interpro
    accession
    IPR055077
    name
    BRCA2_TR2
  • provider
    interpro
    accession
    IPR012340
    name
    NA-bd_OB-fold
  • provider
    interpro
    accession
    IPR015205
    name
    Tower_dom
[1]
Основание утверждения

Аннотация источника

Аннотации функций GO

Выборка с кодами доказательств

Посмотреть структурированные данные

Показано / подготовлено / в ответе источника: 12 / 169 / 169

GO
GOДоказательствоПубликация или правилоКто аннотировал
GO:0004402
histone acetyltransferase activity
Molecular Function		ECO:0000314
NOT|enables		PMID:9824164UniProt
20060718
GO:0002020
protease binding
Molecular Function		ECO:0000353
enables		PMID:15314155UniProt
20100604
GO:0003690
double-stranded DNA binding
Molecular Function		ECO:0000314
enables		PMID:37499663UniProt
20260302
GO:0003697
single-stranded DNA binding
Molecular Function		ECO:0000318
enables		GO_REF:0000033GO_Central
20250320
GO:0003697
single-stranded DNA binding
Molecular Function		ECO:0000314
enables		PMID:20729832UniProt
20101006
GO:0003697
single-stranded DNA binding
Molecular Function		ECO:0000314
enables		PMID:37499663UniProt
20260302
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:10373512UniProt
20070807
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:10373512IntAct
20260725
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:10551859IntAct
20260725
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:11597317UniProt
20070807
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:12242698UniProt
20090624
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:12242698UniProt
20070807
[2] [3]
Основание утверждения

Аннотация источника

Это аннотации источника, а не самостоятельное доказательство причинного механизма. Полный сохранённый ответ доступен в оригиналах.

Исследования из записи белка

Библиографические записи

Посмотреть структурированные данные
  • source
    uniprot
    id
    P51587-citation-8524414
    title
    Identification of the breast cancer susceptibility gene BRCA2.
    pmid
    8524414
    doi
    10.1038/378789a0
    year
    1995
    authors
    • Wooster R.
    • Bignell G.
    • Lancaster J.
    • Swift S.
    • Seal S.
    • Mangion J.
    • Collins N.
    • Gregory S.
    • Gumbs C.
    • Micklem G.
    • Barfoot R.
    • Hamoudi R.
    • Patel S.
    • Rice C.
    • Biggs P.
    • Hashim Y.
    • Smith A.
    • Connor F.
    • Arason A.
    • Gudmundsson J.
    • Ficenec D.
    • Kelsell D.
    • Ford D.
    • Tonin P.
    • Bishop D.T.
    • Spurr N.K.
    • Ponder B.A.J.
    • Eeles R.
    • Peto J.
    • Devilee P.
    • Cornelisse C.
    • Lynch H.
    • Narod S.
    • Lenoir G.
    • Egilsson V.
    • Barkadottir R.B.
    • Easton D.F.
    • Bentley D.R.
    • Futreal P.A.
    • Ashworth A.
    • Stratton M.R.
    journal
    Nature
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/P51587.json
    source snapshot sha256
    befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
  • source
    uniprot
    id
    P51587-citation-8589730
    title
    The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
    pmid
    8589730
    doi
    10.1038/ng0396-333
    year
    1996
    authors
    • Tavtigian S.V.
    • Simard J.
    • Rommens J.
    • Couch F.
    • Shattuck-Eidens D.
    • Neuhausen S.
    • Merajver S.
    • Thorlacius S.
    • Offit K.
    • Stoppa-Lyonnet D.
    • Belanger C.
    • Bell R.
    • Berry S.
    • Bogden R.
    • Chen Q.
    • Davis T.
    • Dumont M.
    • Frye C.
    • Hattier T.
    • Jammulapati S.
    • Janecki T.
    • Jiang P.
    • Kehrer R.
    • Leblanc J.-F.
    • Mitchell J.T.
    • McArthur-Morrison J.
    • Nguyen K.
    • Peng Y.
    • Samson C.
    • Schroeder M.
    • Snyder S.C.
    • Steele L.
    • Stringfellow M.
    • Stroup C.
    • Swedlund B.
    • Swensen J.
    • Teng D.
    • Thomas A.
    • Tran T.
    • Tran T.
    • Tranchant M.
    • Weaver-Feldhaus J.
    • Wong A.K.C.
    • Shizuya H.
    • Eyfjord J.E.
    • Cannon-Albright L.
    • Labrie F.
    • Skolnick M.H.
    • Weber B.
    • Kamb A.
    • Goldar D.E.
    journal
    Nat. Genet.
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/P51587.json
    source snapshot sha256
    befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
  • source
    uniprot
    id
    P51587-citation-15057823
    title
    The DNA sequence and analysis of human chromosome 13.
    pmid
    15057823
    doi
    10.1038/nature02379
    year
    2004
    authors
    • Dunham A.
    • Matthews L.H.
    • Burton J.
    • Ashurst J.L.
    • Howe K.L.
    • Ashcroft K.J.
    • Beare D.M.
    • Burford D.C.
    • Hunt S.E.
    • Griffiths-Jones S.
    • Jones M.C.
    • Keenan S.J.
    • Oliver K.
    • Scott C.E.
    • Ainscough R.
    • Almeida J.P.
    • Ambrose K.D.
    • Andrews D.T.
    • Ashwell R.I.S.
    • Babbage A.K.
    • Bagguley C.L.
    • Bailey J.
    • Bannerjee R.
    • Barlow K.F.
    • Bates K.
    • Beasley H.
    • Bird C.P.
    • Bray-Allen S.
    • Brown A.J.
    • Brown J.Y.
    • Burrill W.
    • Carder C.
    • Carter N.P.
    • Chapman J.C.
    • Clamp M.E.
    • Clark S.Y.
    • Clarke G.
    • Clee C.M.
    • Clegg S.C.
    • Cobley V.
    • Collins J.E.
    • Corby N.
    • Coville G.J.
    • Deloukas P.
    • Dhami P.
    • Dunham I.
    • Dunn M.
    • Earthrowl M.E.
    • Ellington A.G.
    • Faulkner L.
    • Frankish A.G.
    • Frankland J.
    • French L.
    • Garner P.
    • Garnett J.
    • Gilbert J.G.R.
    • Gilson C.J.
    • Ghori J.
    • Grafham D.V.
    • Gribble S.M.
    • Griffiths C.
    • Hall R.E.
    • Hammond S.
    • Harley J.L.
    • Hart E.A.
    • Heath P.D.
    • Howden P.J.
    • Huckle E.J.
    • Hunt P.J.
    • Hunt A.R.
    • Johnson C.
    • Johnson D.
    • Kay M.
    • Kimberley A.M.
    • King A.
    • Laird G.K.
    • Langford C.J.
    • Lawlor S.
    • Leongamornlert D.A.
    • Lloyd D.M.
    • Lloyd C.
    • Loveland J.E.
    • Lovell J.
    • Martin S.
    • Mashreghi-Mohammadi M.
    • McLaren S.J.
    • McMurray A.
    • Milne S.
    • Moore M.J.F.
    • Nickerson T.
    • Palmer S.A.
    • Pearce A.V.
    • Peck A.I.
    • Pelan S.
    • Phillimore B.
    • Porter K.M.
    • Rice C.M.
    • Searle S.
    • Sehra H.K.
    • Shownkeen R.
    • Skuce C.D.
    • Smith M.
    • Steward C.A.
    • Sycamore N.
    • Tester J.
    • Thomas D.W.
    • Tracey A.
    • Tromans A.
    • Tubby B.
    • Wall M.
    • Wallis J.M.
    • West A.P.
    • Whitehead S.L.
    • Willey D.L.
    • Wilming L.
    • Wray P.W.
    • Wright M.W.
    • Young L.
    • Coulson A.
    • Durbin R.M.
    • Hubbard T.
    • Sulston J.E.
    • Beck S.
    • Bentley D.R.
    • Rogers J.
    • Ross M.T.
    journal
    Nature
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/P51587.json
    source snapshot sha256
    befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
  • source
    uniprot
    id
    P51587-citation-7658781
    title
    Linkage to BRCA2 region in hereditary male breast cancer.
    pmid
    7658781
    doi
    10.1016/s0140-6736(95)91383-1
    year
    1995
    authors
    • Thorlacius S.
    • Tryggvadottir L.
    • Olafsdottir G.H.
    • Jonasson J.G.
    • Ogmundsdottir H.M.
    • Tulinius H.
    • Eyfjord J.E.
    journal
    Lancet
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/P51587.json
    source snapshot sha256
    befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
  • source
    uniprot
    id
    P51587-citation-9150155
    title
    Study of a single BRCA2 mutation with high carrier frequency in a small population.
    pmid
    9150155
    doi
    —
    year
    1997
    authors
    • Thorlacius S.
    • Sigurdsson S.
    • Bjarnadottir H.
    • Olafsdottir G.
    • Jonasson J.G.
    • Tryggvadottir L.
    • Tulinius H.
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    Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients.
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    10.1038/ng0597-17
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    1997
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    • Ozcelik H.
    • Schmocker B.
    • Di Nicola N.
    • Shi X.H.
    • Langer B.
    • Moore M.
    • Taylor B.R.
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    • Darlington G.
    • Andrulis I.L.
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    Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2.
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    10584720
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    10.1016/s0140-6736(99)04336-6
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    1999
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    • Jernstroem H.
    • Lerman C.
    • Ghadirian P.
    • Lynch H.T.
    • Weber B.
    • Garber J.
    • Daly M.
    • Olopade O.I.
    • Foulkes W.D.
    • Warner E.
    • Brunet J.S.
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    Lancet
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    P51587-citation-10373512
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    Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.
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    10373512
    doi
    10.1128/mcb.19.7.4633
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    1999
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    • Marston N.J.
    • Richards W.J.
    • Hughes D.
    • Bertwistle D.
    • Marshall C.J.
    • Ashworth A.
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    Mol. Cell. Biol.
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    P51587-citation-11158174
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    De novo recurrent germline mutation of the BRCA2 gene in a patient with early onset breast cancer.
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    11158174
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    10.1136/jmg.38.2.102
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    2001
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    • van der Luijt R.B.
    • van Zon P.H.
    • Jansen R.P.
    • van der Sijs-Bos C.J.
    • Warlam-Rodenhuis C.C.
    • Ausems M.G.
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    J. Med. Genet.
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    P51587-citation-11239456
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    Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.
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    10.1016/s1097-2765(01)00175-7
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    2001
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    • Masson J.Y.
    • McIlwraith M.J.
    • Stasiak A.Z.
    • Stasiak A.
    • Venkitaraman A.R.
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    Mol. Cell
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    P51587-citation-15115758
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    Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.
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    10.1093/hmg/ddh135
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    2004
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    • Hussain S.
    • Wilson J.B.
    • Medhurst A.L.
    • Hejna J.
    • Witt E.
    • Ananth S.
    • Davies A.
    • Masson J.-Y.
    • Moses R.
    • West S.C.
    • de Winter J.P.
    • Ashworth A.
    • Jones N.J.
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    Hum. Mol. Genet.
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    P51587-citation-15199141
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    Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.
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    10.1128/mcb.24.13.5850-5862.2004
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    • Wang X.Z.
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[1]
Основание утверждения

Аннотация источника

Показаны метаданные. Право на текст статьи определяется отдельно.

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Homo sapiens · NCBI 9606Научный профиль →

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  1. UniProt Consortium · P51587

    2026-09-09T03:19:37.686498+00:00 · CC-BY-4.0

    Происхождение и оригинал
    Версия источника
    entry 252; sequence 4
    SHA-256 исходника
    befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    Обработка
    Unmodified provider response; selected fields are projected into the document.
    Сведения о версии
    Native entry and sequence versions retained.

    Посмотреть оригинал JSON · Скачать оригинал

  2. Gene Ontology Consortium / QuickGO · UniProtKB:P51587

    2026-09-09T03:19:39.004762+00:00 · CC-BY-4.0

    Происхождение и оригинал
    SHA-256 исходника
    362e66f46f82c372fb8fc92bb3842b46320fbae8eae85d9497bd550ae9211404
    Обработка
    Unmodified provider response; selected fields are projected into the document.
    Сведения о версии
    No native GO release was supplied; exact response hash and retrieval time are retained.

    Посмотреть оригинал JSON · Скачать оригинал

  3. Gene Ontology Consortium / QuickGO · UniProtKB:P51587

    2026-09-09T03:19:40.324061+00:00 · CC-BY-4.0

    Происхождение и оригинал
    SHA-256 исходника
    f4d7f8c2a54ea95b803629bb8d105b0794cf2d6d68e14ac4e03e501eebeb0594
    Обработка
    Unmodified provider response; selected fields are projected into the document.
    Сведения о версии
    No native GO release was supplied; exact response hash and retrieval time are retained.

    Посмотреть оригинал JSON · Скачать оригинал

Посмотреть структурированные данные
Content version
5ff0ef5d0bff7ec222b7417db7df0f3d9c172bae815e947a7524dcca41881cee
Source version
research-20260909.1
Updated
2026-09-09