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BRCA2 · P51587

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Meet the protein

BRCA2 is UniProt protein record P51587 for Homo sapiens (NCBI 9606). The retained sequence contains 3418 amino acids.

[1]
Evidence for this statement

Source annotation

What is known about function

Function and evidence from UniProt

Inspect structured data
source text
Tumor suppressor protein that maintains genome stability primarily by repairing damaged DNA through homologous recombination (HR) (PubMed:11239456, PubMed:12442171, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:15937124, PubMed:17515903, PubMed:17515904, PubMed:18317453, PubMed:19303847, PubMed:20729832, PubMed:20729858, PubMed:20729859, PubMed:21719596, PubMed:27941124, PubMed:37499663, PubMed:37515771). Facilitates the repair of double-strand breaks (DSBs) by binding and mediating the loading of the RAD51 protein onto single-stranded DNA (ssDNA), thereby promoting the activity of RAD51, which catalyzes DNA strand exchange (PubMed:11239456, PubMed:12442171, PubMed:15937124, PubMed:17515903, PubMed:17515904, PubMed:18317453, PubMed:19303847, PubMed:20729832, PubMed:20729858, PubMed:20729859, PubMed:27941124, PubMed:37499663). BRCA2 nucleates and stabilizes RAD51 on ssDNA directly and delivers RAD51 to ssDNA-double-stranded DNA (dsDNA) junctions by sliding along dsDNA backbone (PubMed:12442171, PubMed:19303847, PubMed:37499663). RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilization of RAD51-ssDNA filaments by blocking ATP hydrolysis (PubMed:20729859). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). Required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability (PubMed:24896180). Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). Also promotes RAD51 loading to telomeric regions, facilitating telomere replication and capping (PubMed:21076401). Also required for homologous recombination during meiosis by promoting the recruitment of RAD51 and DMC1 recombinases to meiotic DSB sites, enabling proper chromosome pairing and crossing over (PubMed:26976601). Also promotes homologous recombination by inactivating the FIGNL1-FIRRM complex to protect RAD51 filament from premature disassembly (PubMed:37515771). Together with NPM1, may also regulate centrosome duplication (PubMed:21084279)
source language
en
evidence codes
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    11239456
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    12442171
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    15115758
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    15199141
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    15671039
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    15937124
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    17515903
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    17515904
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    18317453
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    19303847
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    20729832
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    20729858
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    20729859
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    21076401
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    21084279
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    21719596
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    24485656
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    24896180
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    26976601
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    27941124
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    37499663
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    37515771
[1]
Evidence for this statement

Source annotation

Evidence codes qualify the annotation. This record is not a measurement of an illustrated specimen.

Sequence and version

P51587

Inspect structured data
accession
P51587
name
Breast cancer type 2 susceptibility protein
length
3418
entry version
252
sequence version
4
sequence
MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPN
LFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTV
KTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHI
SESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESL
KKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVV
DTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEP
NDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCD
QNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDC
ILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGL
EIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSY
KGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLT
SSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCEND
PKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLS
NLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYM
RVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNN
LALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVK
QHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLS
EHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSD
CKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKS
TFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDC
NKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISL
SSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENE
DNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQI
KEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAK
ESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTG
NQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFS
HQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNL
CRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTS
VSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYL
SNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAY
PQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIK
KVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKV
FADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFST
ASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLI
SQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQ
NVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQ
DKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSE
NYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILV
GEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKE
RQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTG
RPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKN
NSNQAVAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPR
ISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQ
LADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPK
EFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANI
SETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVG
SPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDV
IIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENT
TKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKK
QAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLL
TEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKF
LDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLI
AASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKL
MHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSV
STPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQP
PRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEK
QFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI
[1]
Evidence for this statement

Source annotation

Genes and domains

Cross-references supplied by UniProt

Inspect structured data
gene symbols
  • BRCA2
gene crossreferences
  • database
    Ensembl
    id
    ENST00000380152.8
    properties
    • key
      ProteinId
      value
      ENSP00000369497.3
    • key
      GeneId
      value
      ENSG00000139618.19
  • database
    Ensembl
    id
    ENST00000544455.6
    properties
    • key
      ProteinId
      value
      ENSP00000439902.1
    • key
      GeneId
      value
      ENSG00000139618.19
  • database
    Ensembl
    id
    ENST00000680887.1
    properties
    • key
      ProteinId
      value
      ENSP00000505508.1
    • key
      GeneId
      value
      ENSG00000139618.19
  • database
    GeneID
    id
    675
    properties
    • key
      Description
      value
      -
interpro domains
  • provider
    interpro
    accession
    IPR015525
    name
    BRCA2
  • provider
    interpro
    accession
    IPR015252
    name
    BRCA2_hlx
  • provider
    interpro
    accession
    IPR036315
    name
    BRCA2_hlx_sf
  • provider
    interpro
    accession
    IPR015187
    name
    BRCA2_OB_1
  • provider
    interpro
    accession
    IPR048262
    name
    BRCA2_OB_2_dom
  • provider
    interpro
    accession
    IPR015188
    name
    BRCA2_OB_3
  • provider
    interpro
    accession
    IPR002093
    name
    BRCA2_repeat
  • provider
    interpro
    accession
    IPR055077
    name
    BRCA2_TR2
  • provider
    interpro
    accession
    IPR012340
    name
    NA-bd_OB-fold
  • provider
    interpro
    accession
    IPR015205
    name
    Tower_dom
[1]
Evidence for this statement

Source annotation

GO function annotations

A sample with evidence codes

Inspect structured data

Shown / materialized / in provider response: 12 / 169 / 169

GO
GOEvidencePublication or ruleAssigned by
GO:0004402
histone acetyltransferase activity
Molecular Function		ECO:0000314
NOT|enables		PMID:9824164UniProt
20060718
GO:0002020
protease binding
Molecular Function		ECO:0000353
enables		PMID:15314155UniProt
20100604
GO:0003690
double-stranded DNA binding
Molecular Function		ECO:0000314
enables		PMID:37499663UniProt
20260302
GO:0003697
single-stranded DNA binding
Molecular Function		ECO:0000318
enables		GO_REF:0000033GO_Central
20250320
GO:0003697
single-stranded DNA binding
Molecular Function		ECO:0000314
enables		PMID:20729832UniProt
20101006
GO:0003697
single-stranded DNA binding
Molecular Function		ECO:0000314
enables		PMID:37499663UniProt
20260302
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:10373512UniProt
20070807
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:10373512IntAct
20260725
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:10551859IntAct
20260725
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:11597317UniProt
20070807
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:12242698UniProt
20090624
GO:0005515
protein binding
Molecular Function		ECO:0000353
enables		PMID:12242698UniProt
20070807
[2] [3]
Evidence for this statement

Source annotation

These are source annotations, not independent proof of a causal mechanism. The complete captured responses are available as originals.

Research cited by the protein record

Bibliographic records

Inspect structured data
  • source
    uniprot
    id
    P51587-citation-8524414
    title
    Identification of the breast cancer susceptibility gene BRCA2.
    pmid
    8524414
    doi
    10.1038/378789a0
    year
    1995
    authors
    • Wooster R.
    • Bignell G.
    • Lancaster J.
    • Swift S.
    • Seal S.
    • Mangion J.
    • Collins N.
    • Gregory S.
    • Gumbs C.
    • Micklem G.
    • Barfoot R.
    • Hamoudi R.
    • Patel S.
    • Rice C.
    • Biggs P.
    • Hashim Y.
    • Smith A.
    • Connor F.
    • Arason A.
    • Gudmundsson J.
    • Ficenec D.
    • Kelsell D.
    • Ford D.
    • Tonin P.
    • Bishop D.T.
    • Spurr N.K.
    • Ponder B.A.J.
    • Eeles R.
    • Peto J.
    • Devilee P.
    • Cornelisse C.
    • Lynch H.
    • Narod S.
    • Lenoir G.
    • Egilsson V.
    • Barkadottir R.B.
    • Easton D.F.
    • Bentley D.R.
    • Futreal P.A.
    • Ashworth A.
    • Stratton M.R.
    journal
    Nature
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/P51587.json
    source snapshot sha256
    befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
  • source
    uniprot
    id
    P51587-citation-8589730
    title
    The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
    pmid
    8589730
    doi
    10.1038/ng0396-333
    year
    1996
    authors
    • Tavtigian S.V.
    • Simard J.
    • Rommens J.
    • Couch F.
    • Shattuck-Eidens D.
    • Neuhausen S.
    • Merajver S.
    • Thorlacius S.
    • Offit K.
    • Stoppa-Lyonnet D.
    • Belanger C.
    • Bell R.
    • Berry S.
    • Bogden R.
    • Chen Q.
    • Davis T.
    • Dumont M.
    • Frye C.
    • Hattier T.
    • Jammulapati S.
    • Janecki T.
    • Jiang P.
    • Kehrer R.
    • Leblanc J.-F.
    • Mitchell J.T.
    • McArthur-Morrison J.
    • Nguyen K.
    • Peng Y.
    • Samson C.
    • Schroeder M.
    • Snyder S.C.
    • Steele L.
    • Stringfellow M.
    • Stroup C.
    • Swedlund B.
    • Swensen J.
    • Teng D.
    • Thomas A.
    • Tran T.
    • Tran T.
    • Tranchant M.
    • Weaver-Feldhaus J.
    • Wong A.K.C.
    • Shizuya H.
    • Eyfjord J.E.
    • Cannon-Albright L.
    • Labrie F.
    • Skolnick M.H.
    • Weber B.
    • Kamb A.
    • Goldar D.E.
    journal
    Nat. Genet.
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/P51587.json
    source snapshot sha256
    befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
  • source
    uniprot
    id
    P51587-citation-15057823
    title
    The DNA sequence and analysis of human chromosome 13.
    pmid
    15057823
    doi
    10.1038/nature02379
    year
    2004
    authors
    • Dunham A.
    • Matthews L.H.
    • Burton J.
    • Ashurst J.L.
    • Howe K.L.
    • Ashcroft K.J.
    • Beare D.M.
    • Burford D.C.
    • Hunt S.E.
    • Griffiths-Jones S.
    • Jones M.C.
    • Keenan S.J.
    • Oliver K.
    • Scott C.E.
    • Ainscough R.
    • Almeida J.P.
    • Ambrose K.D.
    • Andrews D.T.
    • Ashwell R.I.S.
    • Babbage A.K.
    • Bagguley C.L.
    • Bailey J.
    • Bannerjee R.
    • Barlow K.F.
    • Bates K.
    • Beasley H.
    • Bird C.P.
    • Bray-Allen S.
    • Brown A.J.
    • Brown J.Y.
    • Burrill W.
    • Carder C.
    • Carter N.P.
    • Chapman J.C.
    • Clamp M.E.
    • Clark S.Y.
    • Clarke G.
    • Clee C.M.
    • Clegg S.C.
    • Cobley V.
    • Collins J.E.
    • Corby N.
    • Coville G.J.
    • Deloukas P.
    • Dhami P.
    • Dunham I.
    • Dunn M.
    • Earthrowl M.E.
    • Ellington A.G.
    • Faulkner L.
    • Frankish A.G.
    • Frankland J.
    • French L.
    • Garner P.
    • Garnett J.
    • Gilbert J.G.R.
    • Gilson C.J.
    • Ghori J.
    • Grafham D.V.
    • Gribble S.M.
    • Griffiths C.
    • Hall R.E.
    • Hammond S.
    • Harley J.L.
    • Hart E.A.
    • Heath P.D.
    • Howden P.J.
    • Huckle E.J.
    • Hunt P.J.
    • Hunt A.R.
    • Johnson C.
    • Johnson D.
    • Kay M.
    • Kimberley A.M.
    • King A.
    • Laird G.K.
    • Langford C.J.
    • Lawlor S.
    • Leongamornlert D.A.
    • Lloyd D.M.
    • Lloyd C.
    • Loveland J.E.
    • Lovell J.
    • Martin S.
    • Mashreghi-Mohammadi M.
    • McLaren S.J.
    • McMurray A.
    • Milne S.
    • Moore M.J.F.
    • Nickerson T.
    • Palmer S.A.
    • Pearce A.V.
    • Peck A.I.
    • Pelan S.
    • Phillimore B.
    • Porter K.M.
    • Rice C.M.
    • Searle S.
    • Sehra H.K.
    • Shownkeen R.
    • Skuce C.D.
    • Smith M.
    • Steward C.A.
    • Sycamore N.
    • Tester J.
    • Thomas D.W.
    • Tracey A.
    • Tromans A.
    • Tubby B.
    • Wall M.
    • Wallis J.M.
    • West A.P.
    • Whitehead S.L.
    • Willey D.L.
    • Wilming L.
    • Wray P.W.
    • Wright M.W.
    • Young L.
    • Coulson A.
    • Durbin R.M.
    • Hubbard T.
    • Sulston J.E.
    • Beck S.
    • Bentley D.R.
    • Rogers J.
    • Ross M.T.
    journal
    Nature
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/P51587.json
    source snapshot sha256
    befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
  • source
    uniprot
    id
    P51587-citation-7658781
    title
    Linkage to BRCA2 region in hereditary male breast cancer.
    pmid
    7658781
    doi
    10.1016/s0140-6736(95)91383-1
    year
    1995
    authors
    • Thorlacius S.
    • Tryggvadottir L.
    • Olafsdottir G.H.
    • Jonasson J.G.
    • Ogmundsdottir H.M.
    • Tulinius H.
    • Eyfjord J.E.
    journal
    Lancet
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/P51587.json
    source snapshot sha256
    befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
  • source
    uniprot
    id
    P51587-citation-9150155
    title
    Study of a single BRCA2 mutation with high carrier frequency in a small population.
    pmid
    9150155
    doi
    —
    year
    1997
    authors
    • Thorlacius S.
    • Sigurdsson S.
    • Bjarnadottir H.
    • Olafsdottir G.
    • Jonasson J.G.
    • Tryggvadottir L.
    • Tulinius H.
    • Eyfjoerd J.E.
    journal
    Am. J. Hum. Genet.
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/P51587.json
    source snapshot sha256
    befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
  • source
    uniprot
    id
    P51587-citation-9140390
    title
    Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients.
    pmid
    9140390
    doi
    10.1038/ng0597-17
    year
    1997
    authors
    • Ozcelik H.
    • Schmocker B.
    • Di Nicola N.
    • Shi X.H.
    • Langer B.
    • Moore M.
    • Taylor B.R.
    • Narod S.A.
    • Darlington G.
    • Andrulis I.L.
    • Gallinger S.
    • Redston M.
    journal
    Nat. Genet.
    rights reuse state
    metadata_only
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  • source
    uniprot
    id
    P51587-citation-10584720
    title
    Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2.
    pmid
    10584720
    doi
    10.1016/s0140-6736(99)04336-6
    year
    1999
    authors
    • Jernstroem H.
    • Lerman C.
    • Ghadirian P.
    • Lynch H.T.
    • Weber B.
    • Garber J.
    • Daly M.
    • Olopade O.I.
    • Foulkes W.D.
    • Warner E.
    • Brunet J.S.
    • Narod S.A.
    journal
    Lancet
    rights reuse state
    metadata_only
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  • source
    uniprot
    id
    P51587-citation-10373512
    title
    Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.
    pmid
    10373512
    doi
    10.1128/mcb.19.7.4633
    year
    1999
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    • Marston N.J.
    • Richards W.J.
    • Hughes D.
    • Bertwistle D.
    • Marshall C.J.
    • Ashworth A.
    journal
    Mol. Cell. Biol.
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  • source
    uniprot
    id
    P51587-citation-11158174
    title
    De novo recurrent germline mutation of the BRCA2 gene in a patient with early onset breast cancer.
    pmid
    11158174
    doi
    10.1136/jmg.38.2.102
    year
    2001
    authors
    • van der Luijt R.B.
    • van Zon P.H.
    • Jansen R.P.
    • van der Sijs-Bos C.J.
    • Warlam-Rodenhuis C.C.
    • Ausems M.G.
    journal
    J. Med. Genet.
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  • source
    uniprot
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    P51587-citation-11239456
    title
    Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.
    pmid
    11239456
    doi
    10.1016/s1097-2765(01)00175-7
    year
    2001
    authors
    • Davies A.A.
    • Masson J.Y.
    • McIlwraith M.J.
    • Stasiak A.Z.
    • Stasiak A.
    • Venkitaraman A.R.
    • West S.C.
    journal
    Mol. Cell
    rights reuse state
    metadata_only
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    uniprot
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    P51587-citation-15115758
    title
    Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.
    pmid
    15115758
    doi
    10.1093/hmg/ddh135
    year
    2004
    authors
    • Hussain S.
    • Wilson J.B.
    • Medhurst A.L.
    • Hejna J.
    • Witt E.
    • Ananth S.
    • Davies A.
    • Masson J.-Y.
    • Moses R.
    • West S.C.
    • de Winter J.P.
    • Ashworth A.
    • Jones N.J.
    • Mathew C.G.
    journal
    Hum. Mol. Genet.
    rights reuse state
    metadata_only
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  • source
    uniprot
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    P51587-citation-15199141
    title
    Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.
    pmid
    15199141
    doi
    10.1128/mcb.24.13.5850-5862.2004
    year
    2004
    authors
    • Wang X.Z.
    • Andreassen P.R.
    • D'Andrea A.D.
    journal
    Mol. Cell. Biol.
    rights reuse state
    metadata_only
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[1]
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Homo sapiens · NCBI 9606Scientific profile →

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  1. UniProt Consortium · P51587

    2026-09-09T03:19:37.686498+00:00 · CC-BY-4.0

    Provenance and original
    Source version
    entry 252; sequence 4
    Original SHA-256
    befba0a62b75b4f67c7651d0bb175a4ec3ef6a9751be6575af593c9e94cfd82f
    Processing
    Unmodified provider response; selected fields are projected into the document.
    Version details
    Native entry and sequence versions retained.

    View original JSON · Download original

  2. Gene Ontology Consortium / QuickGO · UniProtKB:P51587

    2026-09-09T03:19:39.004762+00:00 · CC-BY-4.0

    Provenance and original
    Original SHA-256
    362e66f46f82c372fb8fc92bb3842b46320fbae8eae85d9497bd550ae9211404
    Processing
    Unmodified provider response; selected fields are projected into the document.
    Version details
    No native GO release was supplied; exact response hash and retrieval time are retained.

    View original JSON · Download original

  3. Gene Ontology Consortium / QuickGO · UniProtKB:P51587

    2026-09-09T03:19:40.324061+00:00 · CC-BY-4.0

    Provenance and original
    Original SHA-256
    f4d7f8c2a54ea95b803629bb8d105b0794cf2d6d68e14ac4e03e501eebeb0594
    Processing
    Unmodified provider response; selected fields are projected into the document.
    Version details
    No native GO release was supplied; exact response hash and retrieval time are retained.

    View original JSON · Download original

Inspect structured data
Content version
b43f8cc75028904e180710fc7872c2211a9b6b168e3abf9de5c9be09e74798d7
Source version
research-20260909.1
Updated
2026-09-09