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FLC · Q9S7Q7

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Meet the protein

FLC is UniProt protein record Q9S7Q7 for Arabidopsis thaliana (NCBI 3702). The retained sequence contains 196 amino acids.

[1]
Evidence for this statement

Source annotation

What is known about function

Function and evidence from UniProt

Inspect structured data
source text
Putative transcription factor that seems to play a central role in the regulation of flowering time in the late-flowering phenotype by interacting with 'FRIGIDA', the autonomous and the vernalization flowering pathways. Inhibits flowering by repressing 'SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1'. At elevated temperatures (e.g. 29 degrees Celsius), maintained at high levels in a JMJ30/JMJ32-dependent manner to prevent extreme precocious flowering (PubMed:25267112)
source language
en
evidence codes
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    10716723
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    11283346
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    19121105
  • evidenceCode
    ECO:0000269
    source
    PubMed
    id
    25267112
[1]
Evidence for this statement

Source annotation

Evidence codes qualify the annotation. This record is not a measurement of an illustrated specimen.

Sequence and version

Q9S7Q7

Inspect structured data
accession
Q9S7Q7
name
MADS-box protein FLOWERING LOCUS C
length
196
entry version
177
sequence version
1
sequence
MGRKKLEIKRIENKSSRQVTFSKRRNGLIEKARQLSVLCDASVALLVVSASGKLYSFSSG
DNLVKILDRYGKQHADDLKALDHQSKALNYGSHYELLELVDSKLVGSNVKNVSIDALVQL
EEHLETALSVTRAKKTELMLKLVENLKEKEKMLKEENQVLASQMENNHHVGAEAEMEMSP
AGQISDNLPVTLPLLN
[1]
Evidence for this statement

Source annotation

Genes and domains

Cross-references supplied by UniProt

Inspect structured data
gene symbols
  • FLC
gene crossreferences
  • database
    GeneID
    id
    830878
    properties
    • key
      Description
      value
      -
interpro domains
  • provider
    interpro
    accession
    IPR050142
    name
    MADS-box/MEF2_TF
  • provider
    interpro
    accession
    IPR033896
    name
    MEF2-like_N
  • provider
    interpro
    accession
    IPR002487
    name
    TF_Kbox
  • provider
    interpro
    accession
    IPR002100
    name
    TF_MADSbox
  • provider
    interpro
    accession
    IPR036879
    name
    TF_MADSbox_sf
[1]
Evidence for this statement

Source annotation

GO function annotations

A sample with evidence codes

Inspect structured data

Shown / materialized / in provider response: 12 / 30 / 30

GO
GOEvidencePublication or ruleAssigned by
GO:0009266
response to temperature stimulus
Biological Process		ECO:0000315
acts_upstream_of_or_within		PMID:16473970TAIR
20060331
GO:0009910
negative regulation of flower development
Biological Process		ECO:0000315
acts_upstream_of_or_within		PMID:12114624TAIR
20060331
GO:0010048
vernalization response
Biological Process		ECO:0000270
acts_upstream_of_or_within		PMID:15734903TAIR
20060331
GO:0042752
regulation of circadian rhythm
Biological Process		ECO:0000315
acts_upstream_of_or_within		PMID:16473970TAIR
20060331
GO:0000976
transcription cis-regulatory region binding
Molecular Function		ECO:0000353
enables		PMID:30356219TAIR
20201218
GO:0000977
RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function		ECO:0000256
enables		GO_REF:0000002InterPro
20260727
GO:0000978
RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function		ECO:0000318
enables		GO_REF:0000033GO_Central
20220414
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function		ECO:0000318
enables		GO_REF:0000033GO_Central
20170829
GO:0003677
DNA binding
Molecular Function		ECO:0000256
enables		GO_REF:0000002InterPro
20260727
GO:0003700
DNA-binding transcription factor activity
Molecular Function		ECO:0000256
enables		GO_REF:0000002InterPro
20260727
GO:0003700
DNA-binding transcription factor activity
Molecular Function		ECO:0000304
enables		PMID:10716723TAIR
20050218
GO:0003700
DNA-binding transcription factor activity
Molecular Function		ECO:0000250
enables		PMID:11118137TAIR
20030606
[2]
Evidence for this statement

Source annotation

These are source annotations, not independent proof of a causal mechanism. The complete captured responses are available as originals.

Research cited by the protein record

Bibliographic records

Inspect structured data
  • source
    uniprot
    id
    Q9S7Q7-citation-10072403
    title
    The FLF MADS box gene: a repressor of flowering in Arabidopsis regulated by vernalization and methylation.
    pmid
    10072403
    doi
    10.1105/tpc.11.3.445
    year
    1999
    authors
    • Sheldon C.C.
    • Burn J.E.
    • Perez P.P.
    • Metzger J.
    • Edwards J.A.
    • Peacock W.J.
    • Dennis E.S.
    journal
    Plant Cell
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
    source snapshot sha256
    2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
  • source
    uniprot
    id
    Q9S7Q7-citation-10330478
    title
    FLOWERING LOCUS C encodes a novel MADS domain protein that acts as a repressor of flowering.
    pmid
    10330478
    doi
    10.1105/tpc.11.5.949
    year
    1999
    authors
    • Michaels S.D.
    • Amasino R.M.
    journal
    Plant Cell
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
    source snapshot sha256
    2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
  • source
    uniprot
    id
    Q9S7Q7-citation-11130714
    title
    Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.
    pmid
    11130714
    doi
    10.1038/35048507
    year
    2000
    authors
    • Tabata S.
    • Kaneko T.
    • Nakamura Y.
    • Kotani H.
    • Kato T.
    • Asamizu E.
    • Miyajima N.
    • Sasamoto S.
    • Kimura T.
    • Hosouchi T.
    • Kawashima K.
    • Kohara M.
    • Matsumoto M.
    • Matsuno A.
    • Muraki A.
    • Nakayama S.
    • Nakazaki N.
    • Naruo K.
    • Okumura S.
    • Shinpo S.
    • Takeuchi C.
    • Wada T.
    • Watanabe A.
    • Yamada M.
    • Yasuda M.
    • Sato S.
    • de la Bastide M.
    • Huang E.
    • Spiegel L.
    • Gnoj L.
    • O'Shaughnessy A.
    • Preston R.
    • Habermann K.
    • Murray J.
    • Johnson D.
    • Rohlfing T.
    • Nelson J.
    • Stoneking T.
    • Pepin K.
    • Spieth J.
    • Sekhon M.
    • Armstrong J.
    • Becker M.
    • Belter E.
    • Cordum H.
    • Cordes M.
    • Courtney L.
    • Courtney W.
    • Dante M.
    • Du H.
    • Edwards J.
    • Fryman J.
    • Haakensen B.
    • Lamar E.
    • Latreille P.
    • Leonard S.
    • Meyer R.
    • Mulvaney E.
    • Ozersky P.
    • Riley A.
    • Strowmatt C.
    • Wagner-McPherson C.
    • Wollam A.
    • Yoakum M.
    • Bell M.
    • Dedhia N.
    • Parnell L.
    • Shah R.
    • Rodriguez M.
    • Hoon See L.
    • Vil D.
    • Baker J.
    • Kirchoff K.
    • Toth K.
    • King L.
    • Bahret A.
    • Miller B.
    • Marra M.A.
    • Martienssen R.
    • McCombie W.R.
    • Wilson R.K.
    • Murphy G.
    • Bancroft I.
    • Volckaert G.
    • Wambutt R.
    • Duesterhoeft A.
    • Stiekema W.
    • Pohl T.
    • Entian K.-D.
    • Terryn N.
    • Hartley N.
    • Bent E.
    • Johnson S.
    • Langham S.-A.
    • McCullagh B.
    • Robben J.
    • Grymonprez B.
    • Zimmermann W.
    • Ramsperger U.
    • Wedler H.
    • Balke K.
    • Wedler E.
    • Peters S.
    • van Staveren M.
    • Dirkse W.
    • Mooijman P.
    • Klein Lankhorst R.
    • Weitzenegger T.
    • Bothe G.
    • Rose M.
    • Hauf J.
    • Berneiser S.
    • Hempel S.
    • Feldpausch M.
    • Lamberth S.
    • Villarroel R.
    • Gielen J.
    • Ardiles W.
    • Bents O.
    • Lemcke K.
    • Kolesov G.
    • Mayer K.F.X.
    • Rudd S.
    • Schoof H.
    • Schueller C.
    • Zaccaria P.
    • Mewes H.-W.
    • Bevan M.
    • Fransz P.F.
    journal
    Nature
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
    source snapshot sha256
    2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
  • source
    uniprot
    id
    Q9S7Q7-citation-27862469
    title
    Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.
    pmid
    27862469
    doi
    10.1111/tpj.13415
    year
    2017
    authors
    • Cheng C.Y.
    • Krishnakumar V.
    • Chan A.P.
    • Thibaud-Nissen F.
    • Schobel S.
    • Town C.D.
    journal
    Plant J.
    rights reuse state
    metadata_only
    source url
    https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
    source snapshot sha256
    2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
  • source
    uniprot
    id
    Q9S7Q7-citation-CI-CI4AM1G71UC0S
    title
    Community-consensus reference genome of Arabidopsis thaliana Col-0.
    pmid
    —
    doi
    —
    year
    FEB-
    authors
      journal
      —
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      source snapshot sha256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    • source
      uniprot
      id
      Q9S7Q7-citation-10716723
      title
      The molecular basis of vernalization: the central role of FLOWERING LOCUS C (FLC).
      pmid
      10716723
      doi
      10.1073/pnas.97.7.3753
      year
      2000
      authors
      • Sheldon C.C.
      • Rouse D.T.
      • Finnegan E.J.
      • Peacock W.J.
      • Dennis E.S.
      journal
      Proc. Natl. Acad. Sci. U.S.A.
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      source snapshot sha256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    • source
      uniprot
      id
      Q9S7Q7-citation-11283346
      title
      Loss of flowering locus c activity eliminates the late-flowering phenotype of frigida and autonomous pathway mutations but not responsiveness to vernalization.
      pmid
      11283346
      doi
      10.1105/tpc.13.4.935
      year
      2001
      authors
      • Michaels S.D.
      • Amasino R.M.
      journal
      Plant Cell
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      source snapshot sha256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    • source
      uniprot
      id
      Q9S7Q7-citation-14593187
      title
      Regulation of flowering time by histone acetylation in Arabidopsis.
      pmid
      14593187
      doi
      10.1126/science.1091109
      year
      2003
      authors
      • He Y.
      • Michaels S.D.
      • Amasino R.M.
      journal
      Science
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      source snapshot sha256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    • source
      uniprot
      id
      Q9S7Q7-citation-14712276
      title
      Vernalization in Arabidopsis thaliana is mediated by the PHD finger protein VIN3.
      pmid
      14712276
      doi
      10.1038/nature02195
      year
      2004
      authors
      • Sung S.
      • Amasino R.M.
      journal
      Nature
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      source snapshot sha256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    • source
      uniprot
      id
      Q9S7Q7-citation-16299497
      title
      Prevention of early flowering by expression of FLOWERING LOCUS C requires methylation of histone H3 K36.
      pmid
      16299497
      doi
      10.1038/ncb1329
      year
      2005
      authors
      • Zhao Z.
      • Yu Y.
      • Meyer D.
      • Wu C.
      • Shen W.-H.
      journal
      Nat. Cell Biol.
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      source snapshot sha256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    • source
      uniprot
      id
      Q9S7Q7-citation-15659097
      title
      HUA2 is required for the expression of floral repressors in Arabidopsis thaliana.
      pmid
      15659097
      doi
      10.1111/j.1365-313x.2004.02300.x
      year
      2005
      authors
      • Doyle M.R.
      • Bizzell C.M.
      • Keller M.R.
      • Michaels S.D.
      • Song J.
      • Noh Y.-S.
      • Amasino R.M.
      journal
      Plant J.
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      source snapshot sha256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    • source
      uniprot
      id
      Q9S7Q7-citation-17996704
      title
      The Arabidopsis RNA-binding protein FCA requires a lysine-specific demethylase 1 homolog to downregulate FLC.
      pmid
      17996704
      doi
      10.1016/j.molcel.2007.10.018
      year
      2007
      authors
      • Liu F.
      • Quesada V.
      • Crevillen P.
      • Baeurle I.
      • Swiezewski S.
      • Dean C.
      journal
      Mol. Cell
      rights reuse state
      metadata_only
      source url
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      source snapshot sha256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    [1]
    Evidence for this statement

    Source annotation

    Only metadata is shown. Article text has a separate reuse decision.

    Organism in the UniProt record

    Arabidopsis thaliana · NCBI 3702Scientific profile →

    Your research question

    Save the article to return to your question and this source version.

    Plan a test

    This is your research plan. Completing these fields does not confirm a hypothesis.

    Sources and versions

    An explanation grounded in the cited sources

    1. UniProt Consortium · Q9S7Q7

      2026-09-09T03:19:39.769546+00:00 · CC-BY-4.0

      Provenance and original
      Source version
      entry 177; sequence 1
      Original SHA-256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
      Processing
      Unmodified provider response; selected fields are projected into the document.
      Version details
      Native entry and sequence versions retained.

      View original JSON · Download original

    2. Gene Ontology Consortium / QuickGO · UniProtKB:Q9S7Q7

      2026-09-09T03:19:40.604412+00:00 · CC-BY-4.0

      Provenance and original
      Original SHA-256
      1bce19d629054daf9bef55482bbda7cd9c4aa6574d0cff5042e009bcd053d026
      Processing
      Unmodified provider response; selected fields are projected into the document.
      Version details
      No native GO release was supplied; exact response hash and retrieval time are retained.

      View original JSON · Download original

    Inspect structured data
    Content version
    bf92accd5cfbe3ddab3a785f1aa991d31e095748b25c1cab9fe3d4c30553f030
    Source version
    research-20260909.1
    Updated
    2026-09-09