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FLC · Q9S7Q7

In brief

FLC is UniProt protein record Q9S7Q7 for Arabidopsis thaliana (NCBI 3702). The retained sequence contains 196 amino acids. [1]

Evidence for this statement

Source annotation

Where to check this statement

uniprot-Q9S7Q7
Captured UniProt JSON: primaryAccession, organism, sequence and FUNCTION comments
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Meet the protein

FLC participates in flowering-time regulation in Arabidopsis thaliana. The retained UniProt annotation describes it as a putative transcription factor that delays flowering by repressing SOC1. This connects whole-plant development with gene regulation. The selected object is protein product Q9S7Q7; its gene, transcript and abundance in a particular plant are separate research objects.

[1]
Evidence for this statement

Editorial synthesis

Where to check this statement

uniprot-Q9S7Q7
Captured UniProt JSON: primaryAccession, organism, sequence and FUNCTION comments

FLC is discussed in relation to the FRIGIDA, autonomous and vernalization pathways. The entry also gives a temperature condition from an individual study and cites the supporting work. Those conditions cannot automatically be extended to every plant or climate. Compare the annotation with the linked FLC lesson while preserving genotype, experimental conditions and source version.

[1]
Evidence for this statement

Editorial synthesis

Where to check this statement

uniprot-Q9S7Q7
Captured UniProt JSON: primaryAccession, organism, sequence and FUNCTION comments

Connect a regulator to a developmental outcome

The retained FLC annotation connects a putative transcription factor with repression of SOC1 and delayed flowering. This describes a regulatory link: a protein affects the expression of another gene, and the developmental consequence is considered at plant level. The gene-regulation lesson asks what was changed and what was measured in a specific experiment. Protein identity, RNA abundance and flowering time are separate entries in that experiment note; one cannot substitute for another. The word “putative” in the retained annotation remains part of its scope.

[1]
Evidence for this statement

EcoGenesis

Where to check this statement

uniprot-Q9S7Q7
Retained UniProt JSON: comments[commentType=FUNCTION], selected accession and entry version as recorded in evidence

Teaching diagram

Evidence for this statement

EcoGenesis

    Original teaching diagram of the relationship described in the retained FUNCTION annotation; no measured rate, geometry or experimental result is shown.
    1. FLC

      Selected putative regulator

    2. SOC1

      Repressed target in the annotation

    3. Flowering time

      Plant-level outcome

    • FLC → SOC1: connects with
    • SOC1 → Flowering time: connects with

    What is known about function

    Function and evidence from UniProt

    Inspect structured data
    Source text
    Putative transcription factor that seems to play a central role in the regulation of flowering time in the late-flowering phenotype by interacting with 'FRIGIDA', the autonomous and the vernalization flowering pathways. Inhibits flowering by repressing 'SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1'. At elevated temperatures (e.g. 29 degrees Celsius), maintained at high levels in a JMJ30/JMJ32-dependent manner to prevent extreme precocious flowering (PubMed:25267112)
    Source language
    en
    evidence codes
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      10716723
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      11283346
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      19121105
    • evidenceCode
      ECO:0000269
      Source
      PubMed
      id
      25267112
    [1]
    Evidence for this statement

    Source annotation

    Where to check this statement

    uniprot-Q9S7Q7
    Captured UniProt JSON: comments[commentType=FUNCTION] and attached evidence codes

    Evidence codes qualify the annotation. This record is not a measurement of an illustrated specimen.

    Sequence and version

    Q9S7Q7

    Inspect structured data
    accession
    Q9S7Q7
    name
    MADS-box protein FLOWERING LOCUS C
    length
    196
    entry version
    177
    sequence version
    1
    Sequence
    MGRKKLEIKRIENKSSRQVTFSKRRNGLIEKARQLSVLCDASVALLVVSASGKLYSFSSG
DNLVKILDRYGKQHADDLKALDHQSKALNYGSHYELLELVDSKLVGSNVKNVSIDALVQL
EEHLETALSVTRAKKTELMLKLVENLKEKEKMLKEENQVLASQMENNHHVGAEAEMEMSP
AGQISDNLPVTLPLLN
    [1]
    Evidence for this statement

    Source annotation

    Where to check this statement

    uniprot-Q9S7Q7
    Captured UniProt JSON: sequence.value, sequence.length, sequenceVersion and entryVersion

    Genes and domains

    Cross-references supplied by UniProt

    Inspect structured data
    gene symbols
    • FLC
    gene crossreferences
    • database
      GeneID
      id
      830878
      properties
      • key
        Description
        value
        -
    interpro domains
    • Provider
      interpro
      accession
      IPR050142
      name
      MADS-box/MEF2_TF
    • Provider
      interpro
      accession
      IPR033896
      name
      MEF2-like_N
    • Provider
      interpro
      accession
      IPR002487
      name
      TF_Kbox
    • Provider
      interpro
      accession
      IPR002100
      name
      TF_MADSbox
    • Provider
      interpro
      accession
      IPR036879
      name
      TF_MADSbox_sf
    [1]
    Evidence for this statement

    Source annotation

    Where to check this statement

    uniprot-Q9S7Q7
    Captured UniProt JSON: genes, features and cross-references

    GO function annotations

    A sample with evidence codes

    Inspect structured data

    Shown / materialized / in provider response: 12 / 30 / 30

    GO
    GOEvidencePublication or ruleAssigned by
    GO:0009266
    response to temperature stimulus
    Biological Process    		ECO:0000315
    acts_upstream_of_or_within    		PMID:16473970TAIR
    20060331
    GO:0009910
    negative regulation of flower development
    Biological Process    		ECO:0000315
    acts_upstream_of_or_within    		PMID:12114624TAIR
    20060331
    GO:0010048
    vernalization response
    Biological Process    		ECO:0000270
    acts_upstream_of_or_within    		PMID:15734903TAIR
    20060331
    GO:0042752
    regulation of circadian rhythm
    Biological Process    		ECO:0000315
    acts_upstream_of_or_within    		PMID:16473970TAIR
    20060331
    GO:0000976
    transcription cis-regulatory region binding
    Molecular Function    		ECO:0000353
    enables    		PMID:30356219TAIR
    20201218
    GO:0000977
    RNA polymerase II transcription regulatory region sequence-specific DNA binding
    Molecular Function    		ECO:0000256
    enables    		GO_REF:0000002InterPro
    20260727
    GO:0000978
    RNA polymerase II cis-regulatory region sequence-specific DNA binding
    Molecular Function    		ECO:0000318
    enables    		GO_REF:0000033GO_Central
    20220414
    GO:0000981
    DNA-binding transcription factor activity, RNA polymerase II-specific
    Molecular Function    		ECO:0000318
    enables    		GO_REF:0000033GO_Central
    20170829
    GO:0003677
    DNA binding
    Molecular Function    		ECO:0000256
    enables    		GO_REF:0000002InterPro
    20260727
    GO:0003700
    DNA-binding transcription factor activity
    Molecular Function    		ECO:0000256
    enables    		GO_REF:0000002InterPro
    20260727
    GO:0003700
    DNA-binding transcription factor activity
    Molecular Function    		ECO:0000304
    enables    		PMID:10716723TAIR
    20050218
    GO:0003700
    DNA-binding transcription factor activity
    Molecular Function    		ECO:0000250
    enables    		PMID:11118137TAIR
    20030606
    [2]
    Evidence for this statement

    Source annotation

    Where to check this statement

    quickgo-Q9S7Q7-1
    Captured QuickGO annotation results: GO ID, qualifier, evidenceCode, reference, assignedBy and date; limited returned pages

    These are source annotations, not independent proof of a causal mechanism. The complete captured responses are available as originals.

    Research cited by the protein record

    Bibliographic records

    Inspect structured data
    • Source
      uniprot
      id
      Q9S7Q7-citation-10072403
      title
      The FLF MADS box gene: a repressor of flowering in Arabidopsis regulated by vernalization and methylation.
      pmid
      10072403
      doi
      10.1105/tpc.11.3.445
      year
      1999
      authors
      • Sheldon C.C.
      • Burn J.E.
      • Perez P.P.
      • Metzger J.
      • Edwards J.A.
      • Peacock W.J.
      • Dennis E.S.
      journal
      Plant Cell
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      Source snapshot SHA-256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    • Source
      uniprot
      id
      Q9S7Q7-citation-10330478
      title
      FLOWERING LOCUS C encodes a novel MADS domain protein that acts as a repressor of flowering.
      pmid
      10330478
      doi
      10.1105/tpc.11.5.949
      year
      1999
      authors
      • Michaels S.D.
      • Amasino R.M.
      journal
      Plant Cell
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      Source snapshot SHA-256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    • Source
      uniprot
      id
      Q9S7Q7-citation-11130714
      title
      Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.
      pmid
      11130714
      doi
      10.1038/35048507
      year
      2000
      authors
      • Tabata S.
      • Kaneko T.
      • Nakamura Y.
      • Kotani H.
      • Kato T.
      • Asamizu E.
      • Miyajima N.
      • Sasamoto S.
      • Kimura T.
      • Hosouchi T.
      • Kawashima K.
      • Kohara M.
      • Matsumoto M.
      • Matsuno A.
      • Muraki A.
      • Nakayama S.
      • Nakazaki N.
      • Naruo K.
      • Okumura S.
      • Shinpo S.
      • Takeuchi C.
      • Wada T.
      • Watanabe A.
      • Yamada M.
      • Yasuda M.
      • Sato S.
      • de la Bastide M.
      • Huang E.
      • Spiegel L.
      • Gnoj L.
      • O'Shaughnessy A.
      • Preston R.
      • Habermann K.
      • Murray J.
      • Johnson D.
      • Rohlfing T.
      • Nelson J.
      • Stoneking T.
      • Pepin K.
      • Spieth J.
      • Sekhon M.
      • Armstrong J.
      • Becker M.
      • Belter E.
      • Cordum H.
      • Cordes M.
      • Courtney L.
      • Courtney W.
      • Dante M.
      • Du H.
      • Edwards J.
      • Fryman J.
      • Haakensen B.
      • Lamar E.
      • Latreille P.
      • Leonard S.
      • Meyer R.
      • Mulvaney E.
      • Ozersky P.
      • Riley A.
      • Strowmatt C.
      • Wagner-McPherson C.
      • Wollam A.
      • Yoakum M.
      • Bell M.
      • Dedhia N.
      • Parnell L.
      • Shah R.
      • Rodriguez M.
      • Hoon See L.
      • Vil D.
      • Baker J.
      • Kirchoff K.
      • Toth K.
      • King L.
      • Bahret A.
      • Miller B.
      • Marra M.A.
      • Martienssen R.
      • McCombie W.R.
      • Wilson R.K.
      • Murphy G.
      • Bancroft I.
      • Volckaert G.
      • Wambutt R.
      • Duesterhoeft A.
      • Stiekema W.
      • Pohl T.
      • Entian K.-D.
      • Terryn N.
      • Hartley N.
      • Bent E.
      • Johnson S.
      • Langham S.-A.
      • McCullagh B.
      • Robben J.
      • Grymonprez B.
      • Zimmermann W.
      • Ramsperger U.
      • Wedler H.
      • Balke K.
      • Wedler E.
      • Peters S.
      • van Staveren M.
      • Dirkse W.
      • Mooijman P.
      • Klein Lankhorst R.
      • Weitzenegger T.
      • Bothe G.
      • Rose M.
      • Hauf J.
      • Berneiser S.
      • Hempel S.
      • Feldpausch M.
      • Lamberth S.
      • Villarroel R.
      • Gielen J.
      • Ardiles W.
      • Bents O.
      • Lemcke K.
      • Kolesov G.
      • Mayer K.F.X.
      • Rudd S.
      • Schoof H.
      • Schueller C.
      • Zaccaria P.
      • Mewes H.-W.
      • Bevan M.
      • Fransz P.F.
      journal
      Nature
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      Source snapshot SHA-256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    • Source
      uniprot
      id
      Q9S7Q7-citation-27862469
      title
      Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.
      pmid
      27862469
      doi
      10.1111/tpj.13415
      year
      2017
      authors
      • Cheng C.Y.
      • Krishnakumar V.
      • Chan A.P.
      • Thibaud-Nissen F.
      • Schobel S.
      • Town C.D.
      journal
      Plant J.
      Reuse status
      metadata_only
      Source URL
      https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
      Source snapshot SHA-256
      2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
    • Source
      uniprot
      id
      Q9S7Q7-citation-CI-CI4AM1G71UC0S
      title
      Community-consensus reference genome of Arabidopsis thaliana Col-0.
      pmid
      —
      doi
      —
      year
      FEB-
      authors
        journal
        —
        Reuse status
        metadata_only
        Source URL
        https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
        Source snapshot SHA-256
        2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
      • Source
        uniprot
        id
        Q9S7Q7-citation-10716723
        title
        The molecular basis of vernalization: the central role of FLOWERING LOCUS C (FLC).
        pmid
        10716723
        doi
        10.1073/pnas.97.7.3753
        year
        2000
        authors
        • Sheldon C.C.
        • Rouse D.T.
        • Finnegan E.J.
        • Peacock W.J.
        • Dennis E.S.
        journal
        Proc. Natl. Acad. Sci. U.S.A.
        Reuse status
        metadata_only
        Source URL
        https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
        Source snapshot SHA-256
        2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
      • Source
        uniprot
        id
        Q9S7Q7-citation-11283346
        title
        Loss of flowering locus c activity eliminates the late-flowering phenotype of frigida and autonomous pathway mutations but not responsiveness to vernalization.
        pmid
        11283346
        doi
        10.1105/tpc.13.4.935
        year
        2001
        authors
        • Michaels S.D.
        • Amasino R.M.
        journal
        Plant Cell
        Reuse status
        metadata_only
        Source URL
        https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
        Source snapshot SHA-256
        2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
      • Source
        uniprot
        id
        Q9S7Q7-citation-14593187
        title
        Regulation of flowering time by histone acetylation in Arabidopsis.
        pmid
        14593187
        doi
        10.1126/science.1091109
        year
        2003
        authors
        • He Y.
        • Michaels S.D.
        • Amasino R.M.
        journal
        Science
        Reuse status
        metadata_only
        Source URL
        https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
        Source snapshot SHA-256
        2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
      • Source
        uniprot
        id
        Q9S7Q7-citation-14712276
        title
        Vernalization in Arabidopsis thaliana is mediated by the PHD finger protein VIN3.
        pmid
        14712276
        doi
        10.1038/nature02195
        year
        2004
        authors
        • Sung S.
        • Amasino R.M.
        journal
        Nature
        Reuse status
        metadata_only
        Source URL
        https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
        Source snapshot SHA-256
        2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
      • Source
        uniprot
        id
        Q9S7Q7-citation-16299497
        title
        Prevention of early flowering by expression of FLOWERING LOCUS C requires methylation of histone H3 K36.
        pmid
        16299497
        doi
        10.1038/ncb1329
        year
        2005
        authors
        • Zhao Z.
        • Yu Y.
        • Meyer D.
        • Wu C.
        • Shen W.-H.
        journal
        Nat. Cell Biol.
        Reuse status
        metadata_only
        Source URL
        https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
        Source snapshot SHA-256
        2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
      • Source
        uniprot
        id
        Q9S7Q7-citation-15659097
        title
        HUA2 is required for the expression of floral repressors in Arabidopsis thaliana.
        pmid
        15659097
        doi
        10.1111/j.1365-313x.2004.02300.x
        year
        2005
        authors
        • Doyle M.R.
        • Bizzell C.M.
        • Keller M.R.
        • Michaels S.D.
        • Song J.
        • Noh Y.-S.
        • Amasino R.M.
        journal
        Plant J.
        Reuse status
        metadata_only
        Source URL
        https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
        Source snapshot SHA-256
        2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
      • Source
        uniprot
        id
        Q9S7Q7-citation-17996704
        title
        The Arabidopsis RNA-binding protein FCA requires a lysine-specific demethylase 1 homolog to downregulate FLC.
        pmid
        17996704
        doi
        10.1016/j.molcel.2007.10.018
        year
        2007
        authors
        • Liu F.
        • Quesada V.
        • Crevillen P.
        • Baeurle I.
        • Swiezewski S.
        • Dean C.
        journal
        Mol. Cell
        Reuse status
        metadata_only
        Source URL
        https://rest.uniprot.org/uniprotkb/Q9S7Q7.json
        Source snapshot SHA-256
        2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
      [1]
      Evidence for this statement

      Source annotation

      Where to check this statement

      uniprot-Q9S7Q7
      Captured UniProt JSON: references and citation cross-references

      Only metadata is shown. Article text has a separate reuse decision.

      How to read these records

      Organism in the UniProt record

      Arabidopsis thaliana · NCBI 3702Scientific profile →

      Your research question

      Save the article to return to your question and this source version.

      Plan a test

      This is your research plan. Completing these fields does not confirm a hypothesis.

      Ask about this material

      Sources and versions

      Editorial draft · human review pending

      1. UniProt Consortium · Q9S7Q7

        2026-09-09T03:19:39.769546+00:00 · CC-BY-4.0

        Provenance and original
        Source version
        entry 177; sequence 1
        Original SHA-256
        2159cce16879e4d5f2b04e2fda6b73b07f5d70e9257555babf2bc9ee7f701aac
        Processing
        Unmodified provider response; selected fields are projected into the document.
        Version details
        Native entry and sequence versions retained.

        View original JSON · Download original

      2. Gene Ontology Consortium / QuickGO · UniProtKB:Q9S7Q7

        2026-09-09T03:19:40.604412+00:00 · CC-BY-4.0

        Provenance and original
        Original SHA-256
        1bce19d629054daf9bef55482bbda7cd9c4aa6574d0cff5042e009bcd053d026
        Processing
        Unmodified provider response; selected fields are projected into the document.
        Version details
        No native GO release was supplied; exact response hash and retrieval time are retained.

        View original JSON · Download original

      Inspect structured data
      Content version
      55d2316b06d6c32a9fd2f39d143f59cb923bb84d1b10462aa6eaa100680133f2
      Source version
      research-20260909.1
      Updated
      2026-10-01